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The discovery of thienopyridine analogues as potent IkappaB kinase beta inhibitors. Part II.
Wu JP, Fleck R, Brickwood J, Capolino A, Catron K, Chen Z, Cywin C, Emeigh J, Foerst M, Ginn J, Hrapchak M, Hickey E, Hao MH, Kashem M, Li J, Liu W, Morwick T, Nelson R, Marshall D, Martin L, Nemoto P, Potocki I, Liuzzi M, Peet GW, Scouten E, Stefany D, Turner M, Weldon S, Zimmitti C, Spero D, Kelly TA. Wu JP, et al. Among authors: chen z. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5547-51. doi: 10.1016/j.bmcl.2009.08.054. Epub 2009 Aug 15. Bioorg Med Chem Lett. 2009. PMID: 19716697
Synthesis, SAR, and series evolution of novel oxadiazole-containing 5-lipoxygenase activating protein inhibitors: discovery of 2-[4-(3-{(r)-1-[4-(2-amino-pyrimidin-5-yl)-phenyl]-1-cyclopropyl-ethyl}-[1,2,4]oxadiazol-5-yl)-pyrazol-1-yl]-N,N-dimethyl-acetamide (BI 665915).
Takahashi H, Riether D, Bartolozzi A, Bosanac T, Berger V, Binetti R, Broadwater J, Chen Z, Crux R, De Lombaert S, Dave R, Dines JA, Fadra-Khan T, Flegg A, Garrigou M, Hao MH, Huber J, Hutzler JM, Kerr S, Kotey A, Liu W, Lo HY, Loke PL, Mahaney PE, Morwick TM, Napier S, Olague A, Pack E, Padyana AK, Thomson DS, Tye H, Wu L, Zindell RM, Abeywardane A, Simpson T. Takahashi H, et al. Among authors: chen z. J Med Chem. 2015 Feb 26;58(4):1669-90. doi: 10.1021/jm501185j. Epub 2015 Feb 11. J Med Chem. 2015. PMID: 25671290
Discovery and optimization of oxadiazole-based FLAP inhibitors.
Bartolozzi A, Abeywardane A, Bosanac T, Broadwater JA, Chen Z, Hutzler JM, Huber JD, Nemoto P, Olague A, Riether D, Simpson T, Takahashi H, Wu L, Zhang Y, Zindell RM. Bartolozzi A, et al. Among authors: chen z. Bioorg Med Chem Lett. 2017 Oct 15;27(20):4652-4659. doi: 10.1016/j.bmcl.2017.09.007. Epub 2017 Sep 8. Bioorg Med Chem Lett. 2017. PMID: 28927794
Dihydrobenzisoxazole-4-one compounds are novel selective inhibitors of aldosterone synthase (CYP11B2) with in vivo activity.
Meyers K, Cogan DA, Burke J, Arenas R, Balestra M, Brown NF, Chen Z, Cerny MA, Clifford HE, Colombo F, Fader L, Frederick KS, Guo X, Goldberg D, Hornberger KR, Kugler S, Lord J, Marshall DR, Moss N, Parmentier JH, Richman JR, Schmenk J, Weldon SM, Yu M, Zhang M. Meyers K, et al. Among authors: chen z. Bioorg Med Chem Lett. 2018 Mar 1;28(5):979-984. doi: 10.1016/j.bmcl.2017.12.015. Epub 2017 Dec 8. Bioorg Med Chem Lett. 2018. PMID: 29254646
Development of an asymmetric synthesis of a chiral quaternary FLAP inhibitor.
Fandrick KR, Mulder JA, Patel ND, Gao J, Konrad M, Archer E, Buono FG, Duran A, Schmid R, Daeubler J, Desrosiers JN, Zeng X, Rodriguez S, Ma S, Qu B, Li Z, Fandrick DR, Grinberg N, Lee H, Bosanac T, Takahashi H, Chen Z, Bartolozzi A, Nemoto P, Busacca CA, Song JJ, Yee NK, Mahaney PE, Senanayake CH. Fandrick KR, et al. Among authors: chen z. J Org Chem. 2015 Feb 6;80(3):1651-60. doi: 10.1021/jo502550h. Epub 2015 Jan 22. J Org Chem. 2015. PMID: 25562342
Optimization of drug-like properties of nonsteroidal glucocorticoid mimetics and identification of a clinical candidate.
Harcken C, Riether D, Liu P, Razavi H, Patel U, Lee T, Bosanac T, Ward Y, Ralph M, Chen Z, Souza D, Nelson RM, Kukulka A, Fadra-Khan TN, Zuvela-Jelaska L, Patel M, Thomson DS, Nabozny GH. Harcken C, et al. Among authors: chen z. ACS Med Chem Lett. 2014 Nov 20;5(12):1318-23. doi: 10.1021/ml500387y. eCollection 2014 Dec 11. ACS Med Chem Lett. 2014. PMID: 25516791 Free PMC article.
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