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4-amido-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-ones as new potent and selective human A3 adenosine receptor antagonists. synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
Lenzi O, Colotta V, Catarzi D, Varano F, Filacchioni G, Martini C, Trincavelli L, Ciampi O, Varani K, Marighetti F, Morizzo E, Moro S. Lenzi O, et al. Among authors: morizzo e. J Med Chem. 2006 Jun 29;49(13):3916-25. doi: 10.1021/jm060373w. J Med Chem. 2006. PMID: 16789747
New 2-arylpyrazolo[3,4-c]quinoline derivatives as potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
Colotta V, Catarzi D, Varano F, Capelli F, Lenzi O, Filacchioni G, Martini C, Trincavelli L, Ciampi O, Pugliese AM, Pedata F, Schiesaro A, Morizzo E, Moro S. Colotta V, et al. Among authors: morizzo e. J Med Chem. 2007 Aug 23;50(17):4061-74. doi: 10.1021/jm070123v. Epub 2007 Aug 1. J Med Chem. 2007. PMID: 17665891
Synthesis, ligand-receptor modeling studies and pharmacological evaluation of novel 4-modified-2-aryl-1,2,4-triazolo[4,3-a]quinoxalin-1-one derivatives as potent and selective human A3 adenosine receptor antagonists.
Colotta V, Catarzi D, Varano F, Lenzi O, Filacchioni G, Martini C, Trincavelli L, Ciampi O, Traini C, Pugliese AM, Pedata F, Morizzo E, Moro S. Colotta V, et al. Among authors: morizzo e. Bioorg Med Chem. 2008 Jun 1;16(11):6086-102. doi: 10.1016/j.bmc.2008.04.039. Epub 2008 Apr 24. Bioorg Med Chem. 2008. PMID: 18468446
Pyrido[2,3-e]-1,2,4-triazolo[4,3-a]pyrazin-1-one as a new scaffold to develop potent and selective human A3 adenosine receptor antagonists. Synthesis, pharmacological evaluation, and ligand-receptor modeling studies.
Colotta V, Lenzi O, Catarzi D, Varano F, Filacchioni G, Martini C, Trincavelli L, Ciampi O, Pugliese AM, Traini C, Pedata F, Morizzo E, Moro S. Colotta V, et al. Among authors: morizzo e. J Med Chem. 2009 Apr 23;52(8):2407-19. doi: 10.1021/jm8014876. J Med Chem. 2009. PMID: 19301821
High Throughput Combinatorial Formatting of PcrV Nanobodies for Efficient Potency Improvement.
De Tavernier E, Detalle L, Morizzo E, Roobrouck A, De Taeye S, Rieger M, Verhaeghe T, Correia A, Van Hegelsom R, Figueirido R, Noens J, Steffensen S, Stöhr T, Van de Velde W, Depla E, Dombrecht B. De Tavernier E, et al. Among authors: morizzo e. J Biol Chem. 2016 Jul 15;291(29):15243-55. doi: 10.1074/jbc.M115.684241. Epub 2016 May 20. J Biol Chem. 2016. PMID: 27226529 Free PMC article.