Kaye SB - Search Results

1

Biomarker-driven early clinical trials in oncology: a paradigm shift in drug development.

Tan DS, Thomas GV, Garrett MD, Banerji U, de Bono JS, Kaye SB, Workman P. Tan DS, et al. Among authors: kaye sb. Cancer J. 2009 Sep-Oct;15(5):406-20. doi: 10.1097/PPO.0b013e3181bd0445. Cancer J. 2009. PMID: 19826361 Review.

2

Tissue-based approaches to study pharmacodynamic endpoints in early phase oncology clinical trials.

Ang JE, Kaye S, Banerji U. Ang JE, et al. Curr Drug Targets. 2012 Nov;13(12):1525-34. doi: 10.2174/138945012803530062. Curr Drug Targets. 2012. PMID: 22974395 Free PMC article. Review.

3

Can molecular biomarker-based patient selection in Phase I trials accelerate anticancer drug development?

Carden CP, Sarker D, Postel-Vinay S, Yap TA, Attard G, Banerji U, Garrett MD, Thomas GV, Workman P, Kaye SB, de Bono JS. Carden CP, et al. Among authors: kaye sb. Drug Discov Today. 2010 Feb;15(3-4):88-97. doi: 10.1016/j.drudis.2009.11.006. Epub 2009 Dec 2. Drug Discov Today. 2010. PMID: 19961955 Review.

4

Prospective validation of a prognostic score to improve patient selection for oncology phase I trials.

Arkenau HT, Barriuso J, Olmos D, Ang JE, de Bono J, Judson I, Kaye S. Arkenau HT, et al. J Clin Oncol. 2009 Jun 1;27(16):2692-6. doi: 10.1200/JCO.2008.19.5081. Epub 2009 Mar 30. J Clin Oncol. 2009. PMID: 19332724

5

A study of the pattern of hospital admissions in a specialist Phase I oncology trials unit: unplanned admissions as an early indicator of patient attrition.

Brunetto AT, Ang JE, Olmos D, Tan D, Barriuso J, Arkenau HT, Yap TA, Molife LR, Banerji U, de Bono J, Judson I, Kaye S. Brunetto AT, et al. Eur J Cancer. 2010 Oct;46(15):2739-45. doi: 10.1016/j.ejca.2010.06.123. Epub 2010 Aug 11. Eur J Cancer. 2010. PMID: 20667711

6

The association of PI3 kinase signaling and chemoresistance in advanced ovarian cancer.

Carden CP, Stewart A, Thavasu P, Kipps E, Pope L, Crespo M, Miranda S, Attard G, Garrett MD, Clarke PA, Workman P, de Bono JS, Gore M, Kaye SB, Banerji U. Carden CP, et al. Among authors: kaye sb. Mol Cancer Ther. 2012 Jul;11(7):1609-17. doi: 10.1158/1535-7163.MCT-11-0996. Epub 2012 May 3. Mol Cancer Ther. 2012. PMID: 22556379 Free PMC article.

7

Phase I trials in patients with relapsed, advanced upper gastrointestinal carcinomas: experience in a specialist unit.

Khan K, Ang JE, Starling N, Sclafani F, Shah K, Judson I, Molife LR, Banerji U, de Bono JS, Cunningham D, Kaye SB. Khan K, et al. Among authors: kaye sb. Gastric Cancer. 2014 Oct;17(4):621-629. doi: 10.1007/s10120-013-0328-9. Epub 2014 Jan 21. Gastric Cancer. 2014. PMID: 24445485 Free PMC article. Clinical Trial.

8

Plasma Metabolomic Changes following PI3K Inhibition as Pharmacodynamic Biomarkers: Preclinical Discovery to Phase I Trial Evaluation.

Ang JE, Pandher R, Ang JC, Asad YJ, Henley AT, Valenti M, Box G, de Haven Brandon A, Baird RD, Friedman L, Derynck M, Vanhaesebroeck B, Eccles SA, Kaye SB, Workman P, de Bono JS, Raynaud FI. Ang JE, et al. Among authors: kaye sb. Mol Cancer Ther. 2016 Jun;15(6):1412-24. doi: 10.1158/1535-7163.MCT-15-0815. Epub 2016 Apr 5. Mol Cancer Ther. 2016. PMID: 27048952 Free PMC article. Clinical Trial.

9

Clinical factors of response in patients with advanced ovarian cancer participating in early phase clinical trials.

George A, Kristeleit R, Rafii S, Michie CO, Bowen R, Michalarea V, van Hagen T, Wong M, Rallis G, Molife LR, Lopez J, Banerji U, Banerjee SN, Gore ME, de Bono JS, Kaye SB, Yap TA. George A, et al. Among authors: kaye sb. Eur J Cancer. 2017 May;76:52-59. doi: 10.1016/j.ejca.2017.01.020. Epub 2017 Mar 6. Eur J Cancer. 2017. PMID: 28273485 Free article.

10

Phase I clinical trials in patients with advanced non-small cell lung cancer treated within a Drug Development Unit: What have we learnt?

Capelan M, Roda D, Geuna E, Rihawi K, Bodla S, Kaye SB, Bhosle J, Banerji U, O'Brien M, de Bono JS, Popat S, Yap TA. Capelan M, et al. Among authors: kaye sb. Lung Cancer. 2017 Sep;111:6-11. doi: 10.1016/j.lungcan.2017.06.005. Epub 2017 Jun 15. Lung Cancer. 2017. PMID: 28838399 Free article. Clinical Trial.

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