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Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils.
Chan PH, Pardon E, Menzer L, De Genst E, Kumita JR, Christodoulou J, Saerens D, Brans A, Bouillenne F, Archer DB, Robinson CV, Muyldermans S, Matagne A, Redfield C, Wyns L, Dobson CM, Dumoulin M. Chan PH, et al. Among authors: brans a. Biochemistry. 2008 Oct 21;47(42):11041-54. doi: 10.1021/bi8005797. Epub 2008 Sep 25. Biochemistry. 2008. PMID: 18816062
A pathway closely related to the (D)-tagatose pathway of gram-negative enterobacteria identified in the gram-positive bacterium Bacillus licheniformis.
Van der Heiden E, Delmarcelle M, Lebrun S, Freichels R, Brans A, Vastenavond CM, Galleni M, Joris B. Van der Heiden E, et al. Among authors: brans a. Appl Environ Microbiol. 2013 Jun;79(11):3511-5. doi: 10.1128/AEM.03918-12. Epub 2013 Mar 22. Appl Environ Microbiol. 2013. PMID: 23524682 Free PMC article.
34 results