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Multivalent binding oligomers inhibit HIV Tat-TAR interaction critical for viral replication.
Wang D, Iera J, Baker H, Hogan P, Ptak R, Yang L, Hartman T, Buckheit RW Jr, Desjardins A, Yang A, Legault P, Yedavalli V, Jeang KT, Appella DH. Wang D, et al. Among authors: hartman t. Bioorg Med Chem Lett. 2009 Dec 15;19(24):6893-7. doi: 10.1016/j.bmcl.2009.10.078. Epub 2009 Oct 23. Bioorg Med Chem Lett. 2009. PMID: 19896372 Free PMC article.
The structure-activity profile of mercaptobenzamides' anti-HIV activity suggests that thermodynamics of metabolism is more important than binding affinity to the target.
Nikolayevskiy H, Robello M, Scerba MT, Pasternak EH, Saha M, Hartman TL, Buchholz CA, Buckheit RW Jr, Durell SR, Appella DH. Nikolayevskiy H, et al. Among authors: hartman tl. Eur J Med Chem. 2019 Sep 15;178:818-837. doi: 10.1016/j.ejmech.2019.06.020. Epub 2019 Jun 9. Eur J Med Chem. 2019. PMID: 31252286 Free PMC article.
Inhibition of tubulin polymerization by select alkenyldiarylmethanes.
Cullen MD, Sarkar T, Hamel E, Hartman TL, Watson KM, Buckheit RW Jr, Pannecouque C, De Clercq E, Cushman M. Cullen MD, et al. Among authors: hartman tl. Bioorg Med Chem Lett. 2008 Jan 15;18(2):469-73. doi: 10.1016/j.bmcl.2007.11.114. Epub 2007 Dec 4. Bioorg Med Chem Lett. 2008. PMID: 18083556 Free PMC article.
Systematic evaluation of methyl ester bioisosteres in the context of developing alkenyldiarylmethanes (ADAMs) as non-nucleoside reverse transcriptase inhibitors (NNRTIs) for anti-HIV-1 chemotherapy.
Hoshi A, Sakamoto T, Takayama J, Xuan M, Okazaki M, Hartman TL, Buckheit RW Jr, Pannecouque C, Cushman M. Hoshi A, et al. Among authors: hartman tl. Bioorg Med Chem. 2016 Jul 1;24(13):3006-3022. doi: 10.1016/j.bmc.2016.05.010. Epub 2016 May 24. Bioorg Med Chem. 2016. PMID: 27234889
Probing Mercaptobenzamides as HIV Inactivators via Nucleocapsid Protein 7.
Saha M, Scerba MT, Shank NI, Hartman TL, Buchholz CA, Buckheit RW Jr, Durell SR, Appella DH. Saha M, et al. Among authors: hartman tl. ChemMedChem. 2017 May 22;12(10):714-721. doi: 10.1002/cmdc.201700141. Epub 2017 Apr 25. ChemMedChem. 2017. PMID: 28395128 Free PMC article.
745 results