Spielmann HP - Search Results

1

Assessing the efficacy of protein farnesyltransferase inhibitors in mouse models of progeria.

Yang SH, Chang SY, Andres DA, Spielmann HP, Young SG, Fong LG. Yang SH, et al. Among authors: spielmann hp. J Lipid Res. 2010 Feb;51(2):400-5. doi: 10.1194/jlr.M002808. Epub 2009 Oct 26. J Lipid Res. 2010. PMID: 19965595 Free PMC article.

2

Increasing the length of progerin's isoprenyl anchor does not worsen bone disease or survival in mice with Hutchinson-Gilford progeria syndrome.

Davies BS, Yang SH, Farber E, Lee R, Buck SB, Andres DA, Spielmann HP, Agnew BJ, Tamanoi F, Fong LG, Young SG. Davies BS, et al. Among authors: spielmann hp. J Lipid Res. 2009 Jan;50(1):126-34. doi: 10.1194/jlr.M800424-JLR200. Epub 2008 Aug 29. J Lipid Res. 2009. PMID: 18757838 Free PMC article.

3

Progerin elicits disease phenotypes of progeria in mice whether or not it is farnesylated.

Yang SH, Andres DA, Spielmann HP, Young SG, Fong LG. Yang SH, et al. Among authors: spielmann hp. J Clin Invest. 2008 Oct;118(10):3291-300. doi: 10.1172/JCI35876. J Clin Invest. 2008. PMID: 18769635 Free PMC article.

4

Activating the synthesis of progerin, the mutant prelamin A in Hutchinson-Gilford progeria syndrome, with antisense oligonucleotides.

Fong LG, Vickers TA, Farber EA, Choi C, Yun UJ, Hu Y, Yang SH, Coffinier C, Lee R, Yin L, Davies BS, Andres DA, Spielmann HP, Bennett CF, Young SG. Fong LG, et al. Among authors: spielmann hp. Hum Mol Genet. 2009 Jul 1;18(13):2462-71. doi: 10.1093/hmg/ddp184. Epub 2009 Apr 17. Hum Mol Genet. 2009. PMID: 19376814 Free PMC article.

5

An accumulation of non-farnesylated prelamin A causes cardiomyopathy but not progeria.

Davies BS, Barnes RH 2nd, Tu Y, Ren S, Andres DA, Spielmann HP, Lammerding J, Wang Y, Young SG, Fong LG. Davies BS, et al. Among authors: spielmann hp. Hum Mol Genet. 2010 Jul 1;19(13):2682-94. doi: 10.1093/hmg/ddq158. Epub 2010 Apr 26. Hum Mol Genet. 2010. PMID: 20421363 Free PMC article.

6

Absence of progeria-like disease phenotypes in knock-in mice expressing a non-farnesylated version of progerin.

Yang SH, Chang SY, Ren S, Wang Y, Andres DA, Spielmann HP, Fong LG, Young SG. Yang SH, et al. Among authors: spielmann hp. Hum Mol Genet. 2011 Feb 1;20(3):436-44. doi: 10.1093/hmg/ddq490. Epub 2010 Nov 18. Hum Mol Genet. 2011. PMID: 21088111 Free PMC article.

7

Inhibitors of protein geranylgeranyltransferase-I lead to prelamin A accumulation in cells by inhibiting ZMPSTE24.

Chang SY, Hudon-Miller SE, Yang SH, Jung HJ, Lee JM, Farber E, Subramanian T, Andres DA, Spielmann HP, Hrycyna CA, Young SG, Fong LG. Chang SY, et al. Among authors: spielmann hp. J Lipid Res. 2012 Jun;53(6):1176-82. doi: 10.1194/jlr.M026161. Epub 2012 Mar 23. J Lipid Res. 2012. PMID: 22448028 Free PMC article.

8

A potent HIV protease inhibitor, darunavir, does not inhibit ZMPSTE24 or lead to an accumulation of farnesyl-prelamin A in cells.

Coffinier C, Hudon SE, Lee R, Farber EA, Nobumori C, Miner JH, Andres DA, Spielmann HP, Hrycyna CA, Fong LG, Young SG. Coffinier C, et al. Among authors: spielmann hp. J Biol Chem. 2008 Apr 11;283(15):9797-804. doi: 10.1074/jbc.M709629200. Epub 2008 Jan 28. J Biol Chem. 2008. PMID: 18230615 Free PMC article.

9

Preventing farnesylation of the dynein adaptor Spindly contributes to the mitotic defects caused by farnesyltransferase inhibitors.

Holland AJ, Reis RM, Niessen S, Pereira C, Andres DA, Spielmann HP, Cleveland DW, Desai A, Gassmann R. Holland AJ, et al. Among authors: spielmann hp. Mol Biol Cell. 2015 May 15;26(10):1845-56. doi: 10.1091/mbc.E14-11-1560. Epub 2015 Mar 25. Mol Biol Cell. 2015. PMID: 25808490 Free PMC article.

10

A tagging-via-substrate approach to detect the farnesylated proteome using two-dimensional electrophoresis coupled with Western blotting.

Onono FO, Morgan MA, Spielmann HP, Andres DA, Subramanian T, Ganser A, Reuter CW. Onono FO, et al. Among authors: spielmann hp. Mol Cell Proteomics. 2010 Apr;9(4):742-51. doi: 10.1074/mcp.M900597-MCP200. Epub 2010 Jan 26. Mol Cell Proteomics. 2010. PMID: 20103566 Free PMC article.

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