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Optimization of 5-vinylaryl-3-pyridinecarbonitriles as PKCtheta inhibitors.
Boschelli DH, Subrath J, Niu C, Wu B, Wang Y, Lee J, Brennan A, Ho M, Deng B, Yang X, Xu X, Leung L, Wang J, Atherton J, Chaudhary D. Boschelli DH, et al. Among authors: subrath j. Bioorg Med Chem Lett. 2010 Mar 15;20(6):1965-8. doi: 10.1016/j.bmcl.2010.01.119. Epub 2010 Jan 28. Bioorg Med Chem Lett. 2010. PMID: 20153643
Optimization of 5-phenyl-3-pyridinecarbonitriles as PKCtheta inhibitors.
Boschelli DH, Wang D, Prashad AS, Subrath J, Wu B, Niu C, Lee J, Yang X, Brennan A, Chaudhary D. Boschelli DH, et al. Among authors: subrath j. Bioorg Med Chem Lett. 2009 Jul 1;19(13):3623-6. doi: 10.1016/j.bmcl.2009.04.126. Epub 2009 May 3. Bioorg Med Chem Lett. 2009. PMID: 19447612
C-5 substituted heteroaryl-3-pyridinecarbonitriles as PKCtheta inhibitors: part II.
Prashad AS, Wang D, Subrath J, Wu B, Lin M, Zhang MY, Kagan N, Lee J, Yang X, Brennan A, Chaudhary D, Xu X, Leung L, Wang J, Boschelli DH. Prashad AS, et al. Among authors: subrath j. Bioorg Med Chem Lett. 2009 Oct 1;19(19):5799-802. doi: 10.1016/j.bmcl.2009.07.113. Epub 2009 Jul 28. Bioorg Med Chem Lett. 2009. PMID: 19703774
First generation 5-vinyl-3-pyridinecarbonitrile PKCtheta inhibitors.
Niu C, Boschelli DH, Tumey LN, Bhagirath N, Subrath J, Shim J, Wang Y, Wu B, Eid C, Lee J, Yang X, Brennan A, Chaudhary D. Niu C, et al. Among authors: subrath j. Bioorg Med Chem Lett. 2009 Oct 15;19(20):5829-32. doi: 10.1016/j.bmcl.2009.08.086. Epub 2009 Aug 29. Bioorg Med Chem Lett. 2009. PMID: 19762237
Discovery and initial optimization of 5,5'-disubstituted aminohydantoins as potent beta-secretase (BACE1) inhibitors.
Nowak P, Cole DC, Aulabaugh A, Bard J, Chopra R, Cowling R, Fan KY, Hu B, Jacobsen S, Jani M, Jin G, Lo MC, Malamas MS, Manas ES, Narasimhan R, Reinhart P, Robichaud AJ, Stock JR, Subrath J, Svenson K, Turner J, Wagner E, Zhou P, Ellingboe JW. Nowak P, et al. Among authors: subrath j. Bioorg Med Chem Lett. 2010 Jan 15;20(2):632-5. doi: 10.1016/j.bmcl.2009.11.052. Epub 2009 Nov 20. Bioorg Med Chem Lett. 2010. PMID: 19959359
Synthesis and evaluation of aryl-naloxamide opiate analgesics targeting truncated exon 11-associated μ opioid receptor (MOR-1) splice variants.
Majumdar S, Subrath J, Le Rouzic V, Polikar L, Burgman M, Nagakura K, Ocampo J, Haselton N, Pasternak AR, Grinnell S, Pan YX, Pasternak GW. Majumdar S, et al. Among authors: subrath j. J Med Chem. 2012 Jul 26;55(14):6352-62. doi: 10.1021/jm300305c. Epub 2012 Jul 16. J Med Chem. 2012. PMID: 22734622 Free PMC article.
Synthesis of Carfentanil Amide Opioids Using the Ugi Multicomponent Reaction.
Váradi A, Palmer TC, Haselton N, Afonin D, Subrath JJ, Le Rouzic V, Hunkele A, Pasternak GW, Marrone GF, Borics A, Majumdar S. Váradi A, et al. Among authors: subrath jj. ACS Chem Neurosci. 2015 Sep 16;6(9):1570-7. doi: 10.1021/acschemneuro.5b00137. Epub 2015 Jul 21. ACS Chem Neurosci. 2015. PMID: 26148793 Free PMC article.
13 results