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ATM signals to TSC2 in the cytoplasm to regulate mTORC1 in response to ROS.
Alexander A, Cai SL, Kim J, Nanez A, Sahin M, MacLean KH, Inoki K, Guan KL, Shen J, Person MD, Kusewitt D, Mills GB, Kastan MB, Walker CL. Alexander A, et al. Among authors: sahin m. Proc Natl Acad Sci U S A. 2010 Mar 2;107(9):4153-8. doi: 10.1073/pnas.0913860107. Epub 2010 Feb 16. Proc Natl Acad Sci U S A. 2010. PMID: 20160076 Free PMC article.
A tuberous sclerosis complex signalling node at the peroxisome regulates mTORC1 and autophagy in response to ROS.
Zhang J, Kim J, Alexander A, Cai S, Tripathi DN, Dere R, Tee AR, Tait-Mulder J, Di Nardo A, Han JM, Kwiatkowski E, Dunlop EA, Dodd KM, Folkerth RD, Faust PL, Kastan MB, Sahin M, Walker CL. Zhang J, et al. Among authors: sahin m. Nat Cell Biol. 2013 Oct;15(10):1186-96. doi: 10.1038/ncb2822. Epub 2013 Aug 18. Nat Cell Biol. 2013. PMID: 23955302 Free PMC article.
TSC1/TSC2 signaling in the CNS.
Han JM, Sahin M. Han JM, et al. Among authors: sahin m. FEBS Lett. 2011 Apr 6;585(7):973-80. doi: 10.1016/j.febslet.2011.02.001. Epub 2011 Feb 15. FEBS Lett. 2011. PMID: 21329690 Free PMC article. Review.
Regulable neural progenitor-specific Tsc1 loss yields giant cells with organellar dysfunction in a model of tuberous sclerosis complex.
Goto J, Talos DM, Klein P, Qin W, Chekaluk YI, Anderl S, Malinowska IA, Di Nardo A, Bronson RT, Chan JA, Vinters HV, Kernie SG, Jensen FE, Sahin M, Kwiatkowski DJ. Goto J, et al. Among authors: sahin m. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):E1070-9. doi: 10.1073/pnas.1106454108. Epub 2011 Oct 24. Proc Natl Acad Sci U S A. 2011. PMID: 22025691 Free PMC article.
Tsc2-Rheb signaling regulates EphA-mediated axon guidance.
Nie D, Di Nardo A, Han JM, Baharanyi H, Kramvis I, Huynh T, Dabora S, Codeluppi S, Pandolfi PP, Pasquale EB, Sahin M. Nie D, et al. Among authors: sahin m. Nat Neurosci. 2010 Feb;13(2):163-72. doi: 10.1038/nn.2477. Epub 2010 Jan 10. Nat Neurosci. 2010. PMID: 20062052 Free PMC article.
Neuronal Tsc1/2 complex controls autophagy through AMPK-dependent regulation of ULK1.
Di Nardo A, Wertz MH, Kwiatkowski E, Tsai PT, Leech JD, Greene-Colozzi E, Goto J, Dilsiz P, Talos DM, Clish CB, Kwiatkowski DJ, Sahin M. Di Nardo A, et al. Among authors: sahin m. Hum Mol Genet. 2014 Jul 15;23(14):3865-74. doi: 10.1093/hmg/ddu101. Epub 2014 Mar 5. Hum Mol Genet. 2014. PMID: 24599401 Free PMC article.
Mechanism-based treatment in tuberous sclerosis complex.
Jülich K, Sahin M. Jülich K, et al. Among authors: sahin m. Pediatr Neurol. 2014 Apr;50(4):290-6. doi: 10.1016/j.pediatrneurol.2013.12.002. Epub 2013 Dec 5. Pediatr Neurol. 2014. PMID: 24486221 Free PMC article. Review.
2,185 results