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Potent orally bioavailable purine nucleoside phosphorylase inhibitor BCX-4208 induces apoptosis in B- and T-lymphocytes--a novel treatment approach for autoimmune diseases, organ transplantation and hematologic malignancies.
Bantia S, Parker C, Upshaw R, Cunningham A, Kotian P, Kilpatrick JM, Morris P, Chand P, Babu YS. Bantia S, et al. Among authors: chand p. Int Immunopharmacol. 2010 Jul;10(7):784-90. doi: 10.1016/j.intimp.2010.04.009. Epub 2010 Apr 22. Int Immunopharmacol. 2010. PMID: 20399911
Design, parallel synthesis, and crystal structures of biphenyl antithrombotics as selective inhibitors of tissue factor FVIIa complex. Part 1: Exploration of S2 pocket pharmacophores.
Kotian PL, Krishnan R, Rowland S, El-Kattan Y, Saini SK, Upshaw R, Bantia S, Arnold S, Babu YS, Chand P. Kotian PL, et al. Among authors: chand p. Bioorg Med Chem. 2009 Jun 1;17(11):3934-58. doi: 10.1016/j.bmc.2009.04.013. Epub 2009 Apr 12. Bioorg Med Chem. 2009. PMID: 19409795
BCX-1812 (RWJ-270201): discovery of a novel, highly potent, orally active, and selective influenza neuraminidase inhibitor through structure-based drug design.
Babu YS, Chand P, Bantia S, Kotian P, Dehghani A, El-Kattan Y, Lin TH, Hutchison TL, Elliott AJ, Parker CD, Ananth SL, Horn LL, Laver GW, Montgomery JA. Babu YS, et al. Among authors: chand p. J Med Chem. 2000 Sep 21;43(19):3482-6. doi: 10.1021/jm0002679. J Med Chem. 2000. PMID: 11000002 No abstract available.
Discovery of highly potent small molecule kallikrein inhibitors.
Zhang J, Krishnan R, Arnold CS, Mattsson E, Kilpatrick JM, Bantia S, Dehghani A, Boudreaux B, Gupta SN, Kotian PL, Chand P, Babu YS. Zhang J, et al. Among authors: chand p. Med Chem. 2006 Nov;2(6):545-53. doi: 10.2174/1573406410602060545. Med Chem. 2006. PMID: 17105435 Review.
500 results