Sunahara RK - Search Results

1

Structural analysis of thermostabilizing mutations of cocaine esterase.

Narasimhan D, Nance MR, Gao D, Ko MC, Macdonald J, Tamburi P, Yoon D, Landry DM, Woods JH, Zhan CG, Tesmer JJ, Sunahara RK. Narasimhan D, et al. Among authors: sunahara rk. Protein Eng Des Sel. 2010 Jul;23(7):537-47. doi: 10.1093/protein/gzq025. Epub 2010 Apr 30. Protein Eng Des Sel. 2010. PMID: 20436035 Free PMC article.

2

Subunit stabilization and polyethylene glycolation of cocaine esterase improves in vivo residence time.

Narasimhan D, Collins GT, Nance MR, Nichols J, Edwald E, Chan J, Ko MC, Woods JH, Tesmer JJ, Sunahara RK. Narasimhan D, et al. Among authors: sunahara rk. Mol Pharmacol. 2011 Dec;80(6):1056-65. doi: 10.1124/mol.111.074997. Epub 2011 Sep 2. Mol Pharmacol. 2011. PMID: 21890748 Free PMC article.

3

The fate of bacterial cocaine esterase (CocE): an in vivo study of CocE-mediated cocaine hydrolysis, CocE pharmacokinetics, and CocE elimination.

Brim RL, Noon KR, Collins GT, Stein A, Nichols J, Narasimhan D, Ko MC, Woods JH, Sunahara RK. Brim RL, et al. Among authors: sunahara rk. J Pharmacol Exp Ther. 2012 Jan;340(1):83-95. doi: 10.1124/jpet.111.186049. Epub 2011 Oct 11. J Pharmacol Exp Ther. 2012. PMID: 21990608 Free PMC article.

4

Long-lasting effects of a PEGylated mutant cocaine esterase (CocE) on the reinforcing and discriminative stimulus effects of cocaine in rats.

Collins GT, Narasimhan D, Cunningham AR, Zaks ME, Nichols J, Ko MC, Sunahara RK, Woods JH. Collins GT, et al. Among authors: sunahara rk. Neuropsychopharmacology. 2012 Apr;37(5):1092-103. doi: 10.1038/npp.2011.226. Epub 2011 Oct 12. Neuropsychopharmacology. 2012. PMID: 21993206 Free PMC article.

5

Bacterial cocaine esterase: a protein-based therapy for cocaine overdose and addiction.

Narasimhan D, Woods JH, Sunahara RK. Narasimhan D, et al. Among authors: sunahara rk. Future Med Chem. 2012 Feb;4(2):137-50. doi: 10.4155/fmc.11.194. Future Med Chem. 2012. PMID: 22300094 Free PMC article. Review.

6

Repeated administration of a mutant cocaine esterase: effects on plasma cocaine levels, cocaine-induced cardiovascular activity, and immune responses in rhesus monkeys.

Collins GT, Brim RL, Noon KR, Narasimhan D, Lukacs NW, Sunahara RK, Woods JH, Ko MC. Collins GT, et al. Among authors: sunahara rk. J Pharmacol Exp Ther. 2012 Jul;342(1):205-13. doi: 10.1124/jpet.112.194639. Epub 2012 Apr 19. J Pharmacol Exp Ther. 2012. PMID: 22518021 Free PMC article.

7

Rapid and robust protection against cocaine-induced lethality in rats by the bacterial cocaine esterase.

Cooper ZD, Narasimhan D, Sunahara RK, Mierzejewski P, Jutkiewicz EM, Larsen NA, Wilson IA, Landry DW, Woods JH. Cooper ZD, et al. Among authors: sunahara rk. Mol Pharmacol. 2006 Dec;70(6):1885-91. doi: 10.1124/mol.106.025999. Epub 2006 Sep 12. Mol Pharmacol. 2006. PMID: 16968810

8

Cocaine esterase: interactions with cocaine and immune responses in mice.

Ko MC, Bowen LD, Narasimhan D, Berlin AA, Lukacs NW, Sunahara RK, Cooper ZD, Woods JH. Ko MC, et al. Among authors: sunahara rk. J Pharmacol Exp Ther. 2007 Feb;320(2):926-33. doi: 10.1124/jpet.106.114223. Epub 2006 Nov 17. J Pharmacol Exp Ther. 2007. PMID: 17114567

9

A bacterial cocaine esterase protects against cocaine-induced epileptogenic activity and lethality.

Jutkiewicz EM, Baladi MG, Cooper ZD, Narasimhan D, Sunahara RK, Woods JH. Jutkiewicz EM, et al. Among authors: sunahara rk. Ann Emerg Med. 2009 Sep;54(3):409-20. doi: 10.1016/j.annemergmed.2008.09.023. Epub 2008 Nov 14. Ann Emerg Med. 2009. PMID: 19013687 Free PMC article.

10

Effects of cocaine esterase following its repeated administration with cocaine in mice.

Ko MC, Narasimhan D, Berlin AA, Lukacs NW, Sunahara RK, Woods JH. Ko MC, et al. Among authors: sunahara rk. Drug Alcohol Depend. 2009 May 1;101(3):202-9. doi: 10.1016/j.drugalcdep.2009.01.002. Epub 2009 Feb 13. Drug Alcohol Depend. 2009. PMID: 19217723 Free PMC article.

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