Schramm VL - Search Results

1

Isofagomine Inhibits Multiple TcdB Variants and Protects Mice from Clostridioides difficile-Induced Mortality.

Paparella AS, Brew I, Hong HA, Ferriera W, Cutting S, Lamiable-Oulaidi F, Popadynec M, Tyler PC, Schramm VL. Paparella AS, et al. Among authors: schramm vl. ACS Infect Dis. 2024 Mar 8;10(3):928-937. doi: 10.1021/acsinfecdis.3c00507. Epub 2024 Feb 9. ACS Infect Dis. 2024. PMID: 38334357

2

Combined inhibition of MTAP and MAT2a mimics synthetic lethality in tumor models via PRMT5 inhibition.

Bedard GT, Gilaj N, Peregrina K, Brew I, Tosti E, Shaffer K, Tyler PC, Edelmann W, Augenlicht LH, Schramm VL. Bedard GT, et al. Among authors: schramm vl. J Biol Chem. 2024 Jan;300(1):105492. doi: 10.1016/j.jbc.2023.105492. Epub 2023 Nov 23. J Biol Chem. 2024. PMID: 38000655 Free PMC article.

3

Phosphate Binding in PNP Alters Transition-State Analogue Affinity and Subunit Cooperativity.

Minnow YVT, Schramm VL, Almo SC, Ghosh A. Minnow YVT, et al. Among authors: schramm vl. Biochemistry. 2023 Nov 7;62(21):3116-3125. doi: 10.1021/acs.biochem.3c00264. Epub 2023 Oct 9. Biochemistry. 2023. PMID: 37812583

4

Decreased Transition-State Analogue Affinity in Isotopically Heavy MTAN with Increased Catalysis.

Brown M, Schramm VL. Brown M, et al. Among authors: schramm vl. Biochemistry. 2023 Oct 17;62(20):2928-2933. doi: 10.1021/acs.biochem.3c00434. Epub 2023 Oct 3. Biochemistry. 2023. PMID: 37788145 Free PMC article.

5

Isofagomine inhibits multiple TcdB variants and protects mice from Clostridioides difficile induced mortality.

Paparella AS, Brew I, Hong HA, Ferriera W, Cutting S, Lamiable-Oulaidi F, Popadynec M, Tyler PC, Schramm VL. Paparella AS, et al. Among authors: schramm vl. bioRxiv [Preprint]. 2023 Sep 19:2023.09.19.558375. doi: 10.1101/2023.09.19.558375. bioRxiv. 2023. PMID: 37781587 Free PMC article. Updated. Preprint.

6

Cell-Effective Transition-State Analogue of Phenylethanolamine N-Methyltransferase.

Mahmoodi N, Minnow YVT, Harijan RK, Bedard GT, Schramm VL. Mahmoodi N, et al. Among authors: schramm vl. Biochemistry. 2023 Aug 1;62(15):2257-2268. doi: 10.1021/acs.biochem.3c00103. Epub 2023 Jul 19. Biochemistry. 2023. PMID: 37467463 Free PMC article.

7

Phosphoinositide and redox dysregulation by the anticancer methylthioadenosine phosphorylase transition state inhibitor.

Salita T, Rustam YH, Hofferek V, Jackson M, Tollestrup I, Sheridan JP, Schramm VL, Evans GB, Reid GE, Munkacsi AB. Salita T, et al. Among authors: schramm vl. Biochim Biophys Acta Mol Cell Biol Lipids. 2023 Sep;1868(9):159346. doi: 10.1016/j.bbalip.2023.159346. Epub 2023 Jun 8. Biochim Biophys Acta Mol Cell Biol Lipids. 2023. PMID: 37301365

8

Residence Times for Femtomolar and Picomolar Inhibitors of MTANs.

Brown M, Tyler PC, Schramm VL. Brown M, et al. Among authors: schramm vl. Biochemistry. 2023 Jun 6;62(11):1776-1785. doi: 10.1021/acs.biochem.3c00145. Epub 2023 May 19. Biochemistry. 2023. PMID: 37204861 Free PMC article.

9

An enzyme-coupled microplate assay for activity and inhibition of hmdUMP hydrolysis by DNPH1.

Wagner AG, Eskandari R, Schramm VL. Wagner AG, et al. Among authors: schramm vl. Anal Biochem. 2023 Jul 1;672:115171. doi: 10.1016/j.ab.2023.115171. Epub 2023 May 3. Anal Biochem. 2023. PMID: 37142196

10

MAT Gain of Activity Mutation in Helicobacter pylori Is Associated with Resistance to MTAN Transition State Analogues.

Feng M, Namanja-Magliano H, Rajagopalan S, Mishra T, Ducati RG, Hirsch BM, Kelly L, Szymczak W, Fajardo JE, Sidoli S, Fiser A, Jacobs WR, Schramm VL. Feng M, et al. Among authors: schramm vl. ACS Infect Dis. 2023 Apr 14;9(4):966-978. doi: 10.1021/acsinfecdis.2c00644. Epub 2023 Mar 15. ACS Infect Dis. 2023. PMID: 36920074 Free PMC article.

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