Habashita H - Search Results

1

Discovery of orally available spirodiketopiperazine-based CCR5 antagonists.

Nishizawa R, Nishiyama T, Hisaichi K, Hirai K, Habashita H, Takaoka Y, Tada H, Sagawa K, Shibayama S, Maeda K, Mitsuya H, Nakai H, Fukushima D, Toda M. Nishizawa R, et al. Among authors: habashita h. Bioorg Med Chem. 2010 Jul 15;18(14):5208-23. doi: 10.1016/j.bmc.2010.05.057. Epub 2010 May 25. Bioorg Med Chem. 2010. PMID: 20542438 Free PMC article.

2

Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5.

Maeda K, Yoshimura K, Shibayama S, Habashita H, Tada H, Sagawa K, Miyakawa T, Aoki M, Fukushima D, Mitsuya H. Maeda K, et al. Among authors: habashita h. J Biol Chem. 2001 Sep 14;276(37):35194-200. doi: 10.1074/jbc.M105670200. Epub 2001 Jul 13. J Biol Chem. 2001. PMID: 11454872 Free article.

3

Discovery of a new chemical lead for a matrix metalloproteinase inhibitor.

Ikura M, Nakatani S, Yamamoto S, Habashita H, Sugiura T, Takahashi K, Ogawa K, Ohno H, Nakai H, Toda M. Ikura M, et al. Among authors: habashita h. Bioorg Med Chem. 2006 Jun 15;14(12):4241-52. doi: 10.1016/j.bmc.2006.01.059. Epub 2006 Feb 14. Bioorg Med Chem. 2006. PMID: 16481176

4

Design, synthesis, and biological evaluation of the combinatorial library with a new spirodiketopiperazine scaffold. Discovery of novel potent and selective low-molecular-weight CCR5 antagonists.

Habashita H, Kokubo M, Hamano S, Hamanaka N, Toda M, Shibayama S, Tada H, Sagawa K, Fukushima D, Maeda K, Mitsuya H. Habashita H, et al. J Med Chem. 2006 Jul 13;49(14):4140-52. doi: 10.1021/jm060051s. J Med Chem. 2006. PMID: 16821774

5

Spirodiketopiperazine-based CCR5 antagonists: Lead optimization from biologically active metabolite.

Nishizawa R, Nishiyama T, Hisaichi K, Matsunaga N, Minamoto C, Habashita H, Takaoka Y, Toda M, Shibayama S, Tada H, Sagawa K, Fukushima D, Maeda K, Mitsuya H. Nishizawa R, et al. Among authors: habashita h. Bioorg Med Chem Lett. 2007 Feb 1;17(3):727-31. doi: 10.1016/j.bmcl.2006.10.084. Epub 2006 Nov 1. Bioorg Med Chem Lett. 2007. PMID: 17118654

6

Spirodiketopiperazine-based CCR5 antagonists: Improvement of their pharmacokinetic profiles.

Nishizawa R, Nishiyama T, Hisaichi K, Hirai K, Habashita H, Takaoka Y, Tada H, Sagawa K, Shibayama S, Maeda K, Mitsuya H, Nakai H, Fukushima D, Toda M. Nishizawa R, et al. Among authors: habashita h. Bioorg Med Chem Lett. 2010 Jan 15;20(2):763-6. doi: 10.1016/j.bmcl.2009.11.018. Epub 2009 Nov 12. Bioorg Med Chem Lett. 2010. PMID: 20005712 Free PMC article.

7

Design and synthesis of novel metalloproteinase inhibitors.

Nakatani S, Ikura M, Yamamoto S, Nishita Y, Itadani S, Habashita H, Sugiura T, Ogawa K, Ohno H, Takahashi K, Nakai H, Toda M. Nakatani S, et al. Among authors: habashita h. Bioorg Med Chem. 2006 Aug 1;14(15):5402-22. doi: 10.1016/j.bmc.2006.03.032. Epub 2006 Apr 18. Bioorg Med Chem. 2006. PMID: 16621578

8

Novel matrix metalloproteinase inhibitors: generation of lead compounds by the in silico fragment-based approach.

Takahashi K, Ikura M, Habashita H, Nishizaki M, Sugiura T, Yamamoto S, Nakatani S, Ogawa K, Ohno H, Nakai H, Toda M. Takahashi K, et al. Among authors: habashita h. Bioorg Med Chem. 2005 Jul 15;13(14):4527-43. doi: 10.1016/j.bmc.2005.04.051. Bioorg Med Chem. 2005. PMID: 15908222

9

Discovery of ONO-7300243 from a Novel Class of Lysophosphatidic Acid Receptor 1 Antagonists: From Hit to Lead.

Terakado M, Suzuki H, Hashimura K, Tanaka M, Ueda H, Kohno H, Fujimoto T, Saga H, Nakade S, Habashita H, Takaoka Y, Seko T. Terakado M, et al. Among authors: habashita h. ACS Med Chem Lett. 2016 Aug 19;7(10):913-918. doi: 10.1021/acsmedchemlett.6b00225. eCollection 2016 Oct 13. ACS Med Chem Lett. 2016. PMID: 27774128 Free PMC article.

10

Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P₁ and S1P₅ Selective Agonist for the Treatment of Autoimmune Diseases.

Kurata H, Kusumi K, Otsuki K, Suzuki R, Kurono M, Komiya T, Hagiya H, Mizuno H, Shioya H, Ono T, Takada Y, Maeda T, Matsunaga N, Kondo T, Tominaga S, Nunoya KI, Kiyoshi H, Komeno M, Nakade S, Habashita H. Kurata H, et al. Among authors: habashita h. J Med Chem. 2017 Dec 14;60(23):9508-9530. doi: 10.1021/acs.jmedchem.7b00785. Epub 2017 Nov 21. J Med Chem. 2017. PMID: 29120624

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