Spahr C - Search Results

1

Ligand-binding mass spectrometry to study biotransformation of fusion protein drugs and guide immunoassay development: strategic approach and application to peptibodies targeting the thrombopoietin receptor.

Hall MP, Gegg C, Walker K, Spahr C, Ortiz R, Patel V, Yu S, Zhang L, Lu H, DeSilva B, Lee JW. Hall MP, et al. Among authors: spahr c. AAPS J. 2010 Dec;12(4):576-85. doi: 10.1208/s12248-010-9218-9. Epub 2010 Jul 13. AAPS J. 2010. PMID: 20625864 Free PMC article.

2

In vitro methionine oxidation of Escherichia coli-derived human stem cell factor: effects on the molecular structure, biological activity, and dimerization.

Hsu YR, Narhi LO, Spahr C, Langley KE, Lu HS. Hsu YR, et al. Among authors: spahr c. Protein Sci. 1996 Jun;5(6):1165-73. doi: 10.1002/pro.5560050619. Protein Sci. 1996. PMID: 8762148 Free PMC article.

3

Heparin is essential for a single keratinocyte growth factor molecule to bind and form a complex with two molecules of the extracellular domain of its receptor.

Hsu YR, Nybo R, Sullivan JK, Costigan V, Spahr CS, Wong C, Jones M, Pentzer AG, Crouse JA, Pacifici RE, Lu HS, Morris CF, Philo JS. Hsu YR, et al. Among authors: spahr cs. Biochemistry. 1999 Feb 23;38(8):2523-34. doi: 10.1021/bi9821317. Biochemistry. 1999. PMID: 10029547

4

Anti-Epo receptor antibodies do not predict Epo receptor expression.

Elliott S, Busse L, Bass MB, Lu H, Sarosi I, Sinclair AM, Spahr C, Um M, Van G, Begley CG. Elliott S, et al. Among authors: spahr c. Blood. 2006 Mar 1;107(5):1892-5. doi: 10.1182/blood-2005-10-4066. Epub 2005 Oct 25. Blood. 2006. PMID: 16249375 Free article.

5

Human Dickkopf-1 (huDKK1) protein: characterization of glycosylation and determination of disulfide linkages in the two cysteine-rich domains.

Haniu M, Horan T, Spahr C, Hui J, Fan W, Chen C, Richards WG, Lu HS. Haniu M, et al. Among authors: spahr c. Protein Sci. 2011 Nov;20(11):1802-13. doi: 10.1002/pro.705. Epub 2011 Sep 27. Protein Sci. 2011. PMID: 21805521 Free PMC article.

6

General LC-MS/MS method approach to quantify therapeutic monoclonal antibodies using a common whole antibody internal standard with application to preclinical studies.

Li H, Ortiz R, Tran L, Hall M, Spahr C, Walker K, Laudemann J, Miller S, Salimi-Moosavi H, Lee JW. Li H, et al. Among authors: spahr c. Anal Chem. 2012 Feb 7;84(3):1267-73. doi: 10.1021/ac202792n. Epub 2012 Jan 25. Anal Chem. 2012. PMID: 22243404

7

Rationale-Based Engineering of a Potent Long-Acting FGF21 Analog for the Treatment of Type 2 Diabetes.

Hecht R, Li YS, Sun J, Belouski E, Hall M, Hager T, Yie J, Wang W, Winters D, Smith S, Spahr C, Tam LT, Shen Z, Stanislaus S, Chinookoswong N, Lau Y, Sickmier A, Michaels ML, Boone T, Véniant MM, Xu J. Hecht R, et al. Among authors: spahr c. PLoS One. 2012;7(11):e49345. doi: 10.1371/journal.pone.0049345. Epub 2012 Nov 27. PLoS One. 2012. PMID: 23209571 Free PMC article.

8

Differential enzyme-linked immunosorbent assay and ligand-binding mass spectrometry for analysis of biotransformation of protein therapeutics: application to various FGF21 modalities.

Hager T, Spahr C, Xu J, Salimi-Moosavi H, Hall M. Hager T, et al. Among authors: spahr c. Anal Chem. 2013 Mar 5;85(5):2731-8. doi: 10.1021/ac303203y. Epub 2013 Feb 19. Anal Chem. 2013. PMID: 23373459

9

Recombinant human lecithin-cholesterol acyltransferase Fc fusion: analysis of N- and O-linked glycans and identification and elimination of a xylose-based O-linked tetrasaccharide core in the linker region.

Spahr C, Kim JJ, Deng S, Kodama P, Xia Z, Tang J, Zhang R, Siu S, Nuanmanee N, Estes B, Stevens J, Zhou M, Lu HS. Spahr C, et al. Protein Sci. 2013 Dec;22(12):1739-53. doi: 10.1002/pro.2373. Protein Sci. 2013. PMID: 24115046 Free PMC article.

10

O-glycosylation of glycine-serine linkers in recombinant Fc-fusion proteins: attachment of glycosaminoglycans and other intermediates with phosphorylation at the xylose sugar subunit.

Spahr C, Shi SD, Lu HS. Spahr C, et al. MAbs. 2014 Jul-Aug;6(4):904-14. doi: 10.4161/mabs.28763. MAbs. 2014. PMID: 24927272 Free PMC article.

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