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Substrate stiffening promotes endothelial monolayer disruption through enhanced physical forces.
Krishnan R, Klumpers DD, Park CY, Rajendran K, Trepat X, van Bezu J, van Hinsbergh VW, Carman CV, Brain JD, Fredberg JJ, Butler JP, van Nieuw Amerongen GP. Krishnan R, et al. Among authors: van bezu j, van hinsbergh vw, van nieuw amerongen gp. Am J Physiol Cell Physiol. 2011 Jan;300(1):C146-54. doi: 10.1152/ajpcell.00195.2010. Epub 2010 Sep 22. Am J Physiol Cell Physiol. 2011. PMID: 20861463 Free PMC article.
ROCK2 primes the endothelium for vascular hyperpermeability responses by raising baseline junctional tension.
Beckers CM, Knezevic N, Valent ET, Tauseef M, Krishnan R, Rajendran K, Hardin CC, Aman J, van Bezu J, Sweetnam P, van Hinsbergh VW, Mehta D, van Nieuw Amerongen GP. Beckers CM, et al. Among authors: van bezu j, van hinsbergh vw, van nieuw amerongen gp. Vascul Pharmacol. 2015 Jul;70:45-54. doi: 10.1016/j.vph.2015.03.017. Epub 2015 Apr 11. Vascul Pharmacol. 2015. PMID: 25869521 Free PMC article.
RhoA, RhoB and RhoC differentially regulate endothelial barrier function.
Pronk MCA, van Bezu JSM, van Nieuw Amerongen GP, van Hinsbergh VWM, Hordijk PL. Pronk MCA, et al. Among authors: van bezu jsm. Small GTPases. 2019 Nov;10(6):466-484. doi: 10.1080/21541248.2017.1339767. Epub 2017 Sep 26. Small GTPases. 2019. PMID: 28949796 Free PMC article.
Effective treatment of edema and endothelial barrier dysfunction with imatinib.
Aman J, van Bezu J, Damanafshan A, Huveneers S, Eringa EC, Vogel SM, Groeneveld AB, Vonk Noordegraaf A, van Hinsbergh VW, van Nieuw Amerongen GP. Aman J, et al. Among authors: van bezu j, van hinsbergh vw, van nieuw amerongen gp. Circulation. 2012 Dec 4;126(23):2728-38. doi: 10.1161/CIRCULATIONAHA.112.134304. Epub 2012 Oct 25. Circulation. 2012. PMID: 23099479
Depletion of Arg/Abl2 improves endothelial cell adhesion and prevents vascular leak during inflammation.
Amado-Azevedo J, van Stalborch AD, Valent ET, Nawaz K, van Bezu J, Eringa EC, Hoevenaars FPM, De Cuyper IM, Hordijk PL, van Hinsbergh VWM, van Nieuw Amerongen GP, Aman J, Margadant C. Amado-Azevedo J, et al. Among authors: van bezu j. Angiogenesis. 2021 Aug;24(3):677-693. doi: 10.1007/s10456-021-09781-x. Epub 2021 Mar 26. Angiogenesis. 2021. PMID: 33770321 Free PMC article.
A CDC42-centered signaling unit is a dominant positive regulator of endothelial integrity.
Amado-Azevedo J, Reinhard NR, van Bezu J, de Menezes RX, van Beusechem VW, van Nieuw Amerongen GP, van Hinsbergh VWM, Hordijk PL. Amado-Azevedo J, et al. Among authors: van bezu j, van hinsbergh vwm, van beusechem vw, van nieuw amerongen gp. Sci Rep. 2017 Aug 31;7(1):10132. doi: 10.1038/s41598-017-10392-0. Sci Rep. 2017. PMID: 28860633 Free PMC article.
Heat-shock protein 27 is a major methylglyoxal-modified protein in endothelial cells.
Schalkwijk CG, van Bezu J, van der Schors RC, Uchida K, Stehouwer CD, van Hinsbergh VW. Schalkwijk CG, et al. Among authors: van bezu j, van der schors rc, van hinsbergh vw. FEBS Lett. 2006 Mar 6;580(6):1565-70. doi: 10.1016/j.febslet.2006.01.086. Epub 2006 Feb 3. FEBS Lett. 2006. PMID: 16487519 Free article.
29 results