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High-resolution structures of Trypanosoma brucei pteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug target.
Dawson A, Tulloch LB, Barrack KL, Hunter WN. Dawson A, et al. Among authors: tulloch lb. Acta Crystallogr D Biol Crystallogr. 2010 Dec;66(Pt 12):1334-40. doi: 10.1107/S0907444910040886. Epub 2010 Nov 16. Acta Crystallogr D Biol Crystallogr. 2010. PMID: 21123874 Free PMC article.
Discovery of potent pteridine reductase inhibitors to guide antiparasite drug development.
Cavazzuti A, Paglietti G, Hunter WN, Gamarro F, Piras S, Loriga M, Allecca S, Corona P, McLuskey K, Tulloch L, Gibellini F, Ferrari S, Costi MP. Cavazzuti A, et al. Proc Natl Acad Sci U S A. 2008 Feb 5;105(5):1448-53. doi: 10.1073/pnas.0704384105. Epub 2008 Feb 1. Proc Natl Acad Sci U S A. 2008. PMID: 18245389 Free PMC article.
The trypanosome alternative oxidase: a potential drug target?
Menzies SK, Tulloch LB, Florence GJ, Smith TK. Menzies SK, et al. Among authors: tulloch lb. Parasitology. 2018 Feb;145(2):175-183. doi: 10.1017/S0031182016002109. Epub 2016 Nov 29. Parasitology. 2018. PMID: 27894362 Review.
Non-natural acetogenin analogues as potent Trypanosoma brucei inhibitors.
Florence GJ, Fraser AL, Gould ER, King EF, Menzies SK, Morris JC, Tulloch LB, Smith TK. Florence GJ, et al. Among authors: tulloch lb. ChemMedChem. 2014 Nov;9(11):2548-56. doi: 10.1002/cmdc.201402272. Epub 2014 Aug 21. ChemMedChem. 2014. PMID: 25145275 Free PMC article.
27 results