Hardcastle A - Search Results

1

Structure of the Ire1 autophosphorylation complex and implications for the unfolded protein response.

Ali MM, Bagratuni T, Davenport EL, Nowak PR, Silva-Santisteban MC, Hardcastle A, McAndrews C, Rowlands MG, Morgan GJ, Aherne W, Collins I, Davies FE, Pearl LH. Ali MM, et al. Among authors: hardcastle a. EMBO J. 2011 Mar 2;30(5):894-905. doi: 10.1038/emboj.2011.18. Epub 2011 Feb 11. EMBO J. 2011. PMID: 21317875 Free PMC article.

2

Identification of autophosphorylation inhibitors of the inositol-requiring enzyme 1 alpha (IRE1α) by high-throughput screening using a DELFIA assay.

Newbatt Y, Hardcastle A, McAndrew PC, Strover JA, Mirza A, Morgan GJ, Burke R, Davies FE, Collins I, van Montfort RL. Newbatt Y, et al. Among authors: hardcastle a. J Biomol Screen. 2013 Mar;18(3):298-308. doi: 10.1177/1087057112465647. Epub 2012 Nov 8. J Biomol Screen. 2013. PMID: 23139381

3

Assays for HSP90 and inhibitors.

Aherne W, Maloney A, Prodromou C, Rowlands MG, Hardcastle A, Boxall K, Clarke P, Walton MI, Pearl L, Workman P. Aherne W, et al. Among authors: hardcastle a. Methods Mol Med. 2003;85:149-61. doi: 10.1385/1-59259-380-1:149. Methods Mol Med. 2003. PMID: 12710206 Review. No abstract available.

4

A duplexed phenotypic screen for the simultaneous detection of inhibitors of the molecular chaperone heat shock protein 90 and modulators of cellular acetylation.

Hardcastle A, Tomlin P, Norris C, Richards J, Cordwell M, Boxall K, Rowlands M, Jones K, Collins I, McDonald E, Workman P, Aherne W. Hardcastle A, et al. Mol Cancer Ther. 2007 Mar;6(3):1112-22. doi: 10.1158/1535-7163.MCT-06-0496. Mol Cancer Ther. 2007. PMID: 17363504

5

Interference by antifolate drugs in a folate competitive protein-binding assay.

Hardcastle A, Clarke S, Aherne W. Hardcastle A, et al. Cancer Chemother Pharmacol. 1997;39(6):552-3. doi: 10.1007/s002800050613. Cancer Chemother Pharmacol. 1997. PMID: 9118469 No abstract available.

6

Solid-phase immunoassays in mechanism-based drug discovery: their application in the development of inhibitors of the molecular chaperone heat-shock protein 90.

Hardcastle A, Boxall K, Richards J, Tomlin P, Sharp S, Clarke P, Workman P, Aherne W. Hardcastle A, et al. Assay Drug Dev Technol. 2005 Jun;3(3):273-85. doi: 10.1089/adt.2005.3.273. Assay Drug Dev Technol. 2005. PMID: 15971989

7

Inhibition of the heat shock protein 90 molecular chaperone in vitro and in vivo by novel, synthetic, potent resorcinylic pyrazole/isoxazole amide analogues.

Sharp SY, Prodromou C, Boxall K, Powers MV, Holmes JL, Box G, Matthews TP, Cheung KM, Kalusa A, James K, Hayes A, Hardcastle A, Dymock B, Brough PA, Barril X, Cansfield JE, Wright L, Surgenor A, Foloppe N, Hubbard RE, Aherne W, Pearl L, Jones K, McDonald E, Raynaud F, Eccles S, Drysdale M, Workman P. Sharp SY, et al. Among authors: hardcastle a. Mol Cancer Ther. 2007 Apr;6(4):1198-211. doi: 10.1158/1535-7163.MCT-07-0149. Mol Cancer Ther. 2007. PMID: 17431102 Free article.

8

Design and synthesis of novel pyrimidine hydroxamic acid inhibitors of histone deacetylases.

Donald AD, Clark VL, Patel S, Day FA, Rowlands MG, Wibata J, Stimson L, Hardcastle A, Eccles SA, McNamara D, Needham LA, Raynaud FI, Aherne W, Moffat DF. Donald AD, et al. Among authors: hardcastle a. Bioorg Med Chem Lett. 2010 Nov 15;20(22):6657-60. doi: 10.1016/j.bmcl.2010.09.016. Epub 2010 Sep 21. Bioorg Med Chem Lett. 2010. PMID: 20884208

9

The measurement of deoxynucleotide (dNTP) pools by radioimmunoassay (RIA).

Aherne W, Hardcastle A, Kelland L, Jackman A. Aherne W, et al. Among authors: hardcastle a. Adv Exp Med Biol. 1994;370:801-4. doi: 10.1007/978-1-4615-2584-4_168. Adv Exp Med Biol. 1994. PMID: 7661027

10

The duration of the inhibition of thymidylate synthase in intact L1210 cells exposed to two different classes of quinazoline analogues.

Kimbell R, Jackman AL, Boyle FT, Hardcastle A, Aherne W. Kimbell R, et al. Among authors: hardcastle a. Adv Exp Med Biol. 1993;338:597-600. doi: 10.1007/978-1-4615-2960-6_122. Adv Exp Med Biol. 1993. PMID: 8304189 No abstract available.

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