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The efficacy of sodium channel blockers to prevent phencyclidine-induced cognitive dysfunction in the rat: potential for novel treatments for schizophrenia.
Large CH, Bison S, Sartori I, Read KD, Gozzi A, Quarta D, Antolini M, Hollands E, Gill CH, Gunthorpe MJ, Idris N, Neill JC, Alvaro GS. Large CH, et al. Among authors: gunthorpe mj. J Pharmacol Exp Ther. 2011 Jul;338(1):100-13. doi: 10.1124/jpet.110.178475. Epub 2011 Apr 12. J Pharmacol Exp Ther. 2011. PMID: 21487071 Free article.
Characterization of SB-705498, a potent and selective vanilloid receptor-1 (VR1/TRPV1) antagonist that inhibits the capsaicin-, acid-, and heat-mediated activation of the receptor.
Gunthorpe MJ, Hannan SL, Smart D, Jerman JC, Arpino S, Smith GD, Brough S, Wright J, Egerton J, Lappin SC, Holland VA, Winborn K, Thompson M, Rami HK, Randall A, Davis JB. Gunthorpe MJ, et al. J Pharmacol Exp Ther. 2007 Jun;321(3):1183-92. doi: 10.1124/jpet.106.116657. Epub 2007 Mar 28. J Pharmacol Exp Ther. 2007. PMID: 17392405
Characterisation of 5-HT3C, 5-HT3D and 5-HT3E receptor subunits: evolution, distribution and function.
Holbrook JD, Gill CH, Zebda N, Spencer JP, Leyland R, Rance KH, Trinh H, Balmer G, Kelly FM, Yusaf SP, Courtenay N, Luck J, Rhodes A, Modha S, Moore SE, Sanger GJ, Gunthorpe MJ. Holbrook JD, et al. Among authors: gunthorpe mj. J Neurochem. 2009 Jan;108(2):384-96. doi: 10.1111/j.1471-4159.2008.05775.x. Epub 2008 Nov 29. J Neurochem. 2009. PMID: 19012743 Free article.
Reducing voltage-dependent potassium channel Kv3.4 levels ameliorates synapse loss in a mouse model of Alzheimer's disease.
Yeap J, Sathyaprakash C, Toombs J, Tulloch J, Scutariu C, Rose J, Burr K, Davies C, Colom-Cadena M, Chandran S, Large CH, Rowan MJM, Gunthorpe MJ, Spires-Jones TL. Yeap J, et al. Among authors: gunthorpe mj. Brain Neurosci Adv. 2022 Mar 24;6:23982128221086464. doi: 10.1177/23982128221086464. eCollection 2022 Jan-Dec. Brain Neurosci Adv. 2022. PMID: 35359460 Free PMC article.
The binding and mechanism of a positive allosteric modulator of Kv3 channels.
Liang Q, Chi G, Cirqueira L, Zhi L, Marasco A, Pilati N, Gunthorpe MJ, Alvaro G, Large CH, Sauer DB, Treptow W, Covarrubias M. Liang Q, et al. Among authors: gunthorpe mj. Nat Commun. 2024 Mar 21;15(1):2533. doi: 10.1038/s41467-024-46813-8. Nat Commun. 2024. PMID: 38514618 Free PMC article.
43 results