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Disulfide bonds reduce the toxicity of the amyloid fibrils formed by an extracellular protein.
Mossuto MF, Bolognesi B, Guixer B, Dhulesia A, Agostini F, Kumita JR, Tartaglia GG, Dumoulin M, Dobson CM, Salvatella X. Mossuto MF, et al. Among authors: dumoulin m. Angew Chem Int Ed Engl. 2011 Jul 25;50(31):7048-51. doi: 10.1002/anie.201100986. Epub 2011 Jun 10. Angew Chem Int Ed Engl. 2011. PMID: 21671315 Free PMC article. No abstract available.
The non-core regions of human lysozyme amyloid fibrils influence cytotoxicity.
Mossuto MF, Dhulesia A, Devlin G, Frare E, Kumita JR, de Laureto PP, Dumoulin M, Fontana A, Dobson CM, Salvatella X. Mossuto MF, et al. Among authors: dumoulin m. J Mol Biol. 2010 Oct 8;402(5):783-96. doi: 10.1016/j.jmb.2010.07.005. Epub 2010 Jul 17. J Mol Biol. 2010. PMID: 20624399 Free PMC article.
Population of nonnative states of lysozyme variants drives amyloid fibril formation.
Buell AK, Dhulesia A, Mossuto MF, Cremades N, Kumita JR, Dumoulin M, Welland ME, Knowles TPJ, Salvatella X, Dobson CM. Buell AK, et al. Among authors: dumoulin m. J Am Chem Soc. 2011 May 25;133(20):7737-7743. doi: 10.1021/ja109620d. Epub 2011 Apr 29. J Am Chem Soc. 2011. PMID: 21528861 Free PMC article.
Engineering a camelid antibody fragment that binds to the active site of human lysozyme and inhibits its conversion into amyloid fibrils.
Chan PH, Pardon E, Menzer L, De Genst E, Kumita JR, Christodoulou J, Saerens D, Brans A, Bouillenne F, Archer DB, Robinson CV, Muyldermans S, Matagne A, Redfield C, Wyns L, Dobson CM, Dumoulin M. Chan PH, et al. Among authors: dumoulin m. Biochemistry. 2008 Oct 21;47(42):11041-54. doi: 10.1021/bi8005797. Epub 2008 Sep 25. Biochemistry. 2008. PMID: 18816062
161 results