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β2 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo.
Murray DR, Mummidi S, Valente AJ, Yoshida T, Somanna NK, Delafontaine P, Dinarello CA, Chandrasekar B. Murray DR, et al. Among authors: delafontaine p. J Mol Cell Cardiol. 2012 Jan;52(1):206-18. doi: 10.1016/j.yjmcc.2011.09.022. Epub 2011 Oct 8. J Mol Cell Cardiol. 2012. PMID: 22004899 Free PMC article.
EMMPRIN activates multiple transcription factors in cardiomyocytes, and induces interleukin-18 expression via Rac1-dependent PI3K/Akt/IKK/NF-kappaB andMKK7/JNK/AP-1 signaling.
Venkatesan B, Valente AJ, Prabhu SD, Shanmugam P, Delafontaine P, Chandrasekar B. Venkatesan B, et al. Among authors: delafontaine p. J Mol Cell Cardiol. 2010 Oct;49(4):655-63. doi: 10.1016/j.yjmcc.2010.05.007. Epub 2010 Jun 9. J Mol Cell Cardiol. 2010. PMID: 20538003 Free PMC article.
Interleukin-18 induces EMMPRIN expression in primary cardiomyocytes via JNK/Sp1 signaling and MMP-9 in part via EMMPRIN and through AP-1 and NF-kappaB activation.
Reddy VS, Prabhu SD, Mummidi S, Valente AJ, Venkatesan B, Shanmugam P, Delafontaine P, Chandrasekar B. Reddy VS, et al. Among authors: delafontaine p. Am J Physiol Heart Circ Physiol. 2010 Oct;299(4):H1242-54. doi: 10.1152/ajpheart.00451.2010. Epub 2010 Aug 6. Am J Physiol Heart Circ Physiol. 2010. PMID: 20693392 Free PMC article.
Angiotensin II induced catabolic effect and muscle atrophy are redox dependent.
Semprun-Prieto LC, Sukhanov S, Yoshida T, Rezk BM, Gonzalez-Villalobos RA, Vaughn C, Michael Tabony A, Delafontaine P. Semprun-Prieto LC, et al. Among authors: delafontaine p. Biochem Biophys Res Commun. 2011 Jun 3;409(2):217-21. doi: 10.1016/j.bbrc.2011.04.122. Epub 2011 May 6. Biochem Biophys Res Commun. 2011. PMID: 21570954 Free PMC article.
197 results