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β2 adrenergic activation induces the expression of IL-18 binding protein, a potent inhibitor of isoproterenol induced cardiomyocyte hypertrophy in vitro and myocardial hypertrophy in vivo.
Murray DR, Mummidi S, Valente AJ, Yoshida T, Somanna NK, Delafontaine P, Dinarello CA, Chandrasekar B. Murray DR, et al. Among authors: mummidi s. J Mol Cell Cardiol. 2012 Jan;52(1):206-18. doi: 10.1016/j.yjmcc.2011.09.022. Epub 2011 Oct 8. J Mol Cell Cardiol. 2012. PMID: 22004899 Free PMC article.
Pressure overload induces IL-18 and IL-18R expression, but markedly suppresses IL-18BP expression in a rabbit model. IL-18 potentiates TNF-α-induced cardiomyocyte death.
Yoshida T, Friehs I, Mummidi S, del Nido PJ, Addulnour-Nakhoul S, Delafontaine P, Valente AJ, Chandrasekar B. Yoshida T, et al. Among authors: mummidi s. J Mol Cell Cardiol. 2014 Oct;75:141-51. doi: 10.1016/j.yjmcc.2014.07.007. Epub 2014 Aug 7. J Mol Cell Cardiol. 2014. PMID: 25108227 Free PMC article.
IL-17 stimulates MMP-1 expression in primary human cardiac fibroblasts via p38 MAPK- and ERK1/2-dependent C/EBP-beta , NF-kappaB, and AP-1 activation.
Cortez DM, Feldman MD, Mummidi S, Valente AJ, Steffensen B, Vincenti M, Barnes JL, Chandrasekar B. Cortez DM, et al. Among authors: mummidi s. Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3356-65. doi: 10.1152/ajpheart.00928.2007. Epub 2007 Oct 5. Am J Physiol Heart Circ Physiol. 2007. PMID: 17921324 Free article.
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