Hancock JF - Search Results

1

A polybasic domain or palmitoylation is required in addition to the CAAX motif to localize p21ras to the plasma membrane.

Hancock JF, Paterson H, Marshall CJ. Hancock JF, et al. Cell. 1990 Oct 5;63(1):133-9. doi: 10.1016/0092-8674(90)90294-o. Cell. 1990. PMID: 2208277

2

A CAAX or a CAAL motif and a second signal are sufficient for plasma membrane targeting of ras proteins.

Hancock JF, Cadwallader K, Paterson H, Marshall CJ. Hancock JF, et al. EMBO J. 1991 Dec;10(13):4033-9. doi: 10.1002/j.1460-2075.1991.tb04979.x. EMBO J. 1991. PMID: 1756714 Free PMC article.

3

Methylation and proteolysis are essential for efficient membrane binding of prenylated p21K-ras(B).

Hancock JF, Cadwallader K, Marshall CJ. Hancock JF, et al. EMBO J. 1991 Mar;10(3):641-6. doi: 10.1002/j.1460-2075.1991.tb07992.x. EMBO J. 1991. PMID: 2001678 Free PMC article.

4

Targeting of oncoproteins to membranes by fatty acylation.

Magee AI, Gutierrez L, Marshall CJ, Hancock JF. Magee AI, et al. Among authors: hancock jf. J Cell Sci Suppl. 1989;11:149-60. doi: 10.1242/jcs.1989.supplement_11.12. J Cell Sci Suppl. 1989. PMID: 2533203 Review.

5

All ras proteins are polyisoprenylated but only some are palmitoylated.

Hancock JF, Magee AI, Childs JE, Marshall CJ. Hancock JF, et al. Cell. 1989 Jun 30;57(7):1167-77. doi: 10.1016/0092-8674(89)90054-8. Cell. 1989. PMID: 2661017

6

Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis.

Gutierrez L, Magee AI, Marshall CJ, Hancock JF. Gutierrez L, et al. Among authors: hancock jf. EMBO J. 1989 Apr;8(4):1093-8. doi: 10.1002/j.1460-2075.1989.tb03478.x. EMBO J. 1989. PMID: 2663468 Free PMC article.

7

The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product.

Calés C, Hancock JF, Marshall CJ, Hall A. Calés C, et al. Among authors: hancock jf. Nature. 1988 Apr 7;332(6164):548-51. doi: 10.1038/332548a0. Nature. 1988. PMID: 2833702

8

Mutant but not normal p21 ras elevates inositol phospholipid breakdown in two different cell systems.

Hancock JF, Marshall CJ, McKay IA, Gardner S, Houslay MD, Hall A, Wakelam MJ. Hancock JF, et al. Oncogene. 1988 Aug;3(2):187-93. Oncogene. 1988. PMID: 2842715

9

Analysis of mammalian ras effector function.

Hall A, Calés C, Hancock JF, Lloyd A, Self A, Gardener S, Houslay MD, Wakelam MJ, Marshall CJ. Hall A, et al. Among authors: hancock jf. Cold Spring Harb Symp Quant Biol. 1988;53 Pt 2:855-62. doi: 10.1101/sqb.1988.053.01.098. Cold Spring Harb Symp Quant Biol. 1988. PMID: 3076100 No abstract available.

10

N-terminally myristoylated Ras proteins require palmitoylation or a polybasic domain for plasma membrane localization.

Cadwallader KA, Paterson H, Macdonald SG, Hancock JF. Cadwallader KA, et al. Among authors: hancock jf. Mol Cell Biol. 1994 Jul;14(7):4722-30. doi: 10.1128/mcb.14.7.4722-4730.1994. Mol Cell Biol. 1994. PMID: 8007974 Free PMC article.

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