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IL-10 elicits IFNγ-dependent tumor immune surveillance.
Mumm JB, Emmerich J, Zhang X, Chan I, Wu L, Mauze S, Blaisdell S, Basham B, Dai J, Grein J, Sheppard C, Hong K, Cutler C, Turner S, LaFace D, Kleinschek M, Judo M, Ayanoglu G, Langowski J, Gu D, Paporello B, Murphy E, Sriram V, Naravula S, Desai B, Medicherla S, Seghezzi W, McClanahan T, Cannon-Carlson S, Beebe AM, Oft M. Mumm JB, et al. Cancer Cell. 2011 Dec 13;20(6):781-96. doi: 10.1016/j.ccr.2011.11.003. Cancer Cell. 2011. PMID: 22172723 Free article.
PEGylated IL-10 (Pegilodecakin) Induces Systemic Immune Activation, CD8+ T Cell Invigoration and Polyclonal T Cell Expansion in Cancer Patients.
Naing A, Infante JR, Papadopoulos KP, Chan IH, Shen C, Ratti NP, Rojo B, Autio KA, Wong DJ, Patel MR, Ott PA, Falchook GS, Pant S, Hung A, Pekarek KL, Wu V, Adamow M, McCauley S, Mumm JB, Wong P, Van Vlasselaer P, Leveque J, Tannir NM, Oft M. Naing A, et al. Among authors: mumm jb. Cancer Cell. 2018 Nov 12;34(5):775-791.e3. doi: 10.1016/j.ccell.2018.10.007. Cancer Cell. 2018. PMID: 30423297 Free PMC article.
IL-33 induces IL-13-dependent cutaneous fibrosis.
Rankin AL, Mumm JB, Murphy E, Turner S, Yu N, McClanahan TK, Bourne PA, Pierce RH, Kastelein R, Pflanz S. Rankin AL, et al. Among authors: mumm jb. J Immunol. 2010 Feb 1;184(3):1526-35. doi: 10.4049/jimmunol.0903306. Epub 2009 Dec 30. J Immunol. 2010. PMID: 20042577
Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells.
Chan IH, Jain R, Tessmer MS, Gorman D, Mangadu R, Sathe M, Vives F, Moon C, Penaflor E, Turner S, Ayanoglu G, Chang C, Basham B, Mumm JB, Pierce RH, Yearley JH, McClanahan TK, Phillips JH, Cua DJ, Bowman EP, Kastelein RA, LaFace D. Chan IH, et al. Among authors: mumm jb. Mucosal Immunol. 2014 Jul;7(4):842-56. doi: 10.1038/mi.2013.101. Epub 2013 Nov 27. Mucosal Immunol. 2014. PMID: 24280935 Free article.
Killing from within.
Mumm JB, Emmerich J, Oft M. Mumm JB, et al. Oncoimmunology. 2012 Dec 1;1(9):1598-1600. doi: 10.4161/onci.21423. Oncoimmunology. 2012. PMID: 23264906 Free PMC article.
28 results