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Protein aggregates in Huntington's disease.
Arrasate M, Finkbeiner S. Arrasate M, et al. Among authors: finkbeiner s. Exp Neurol. 2012 Nov;238(1):1-11. doi: 10.1016/j.expneurol.2011.12.013. Epub 2011 Dec 19. Exp Neurol. 2012. PMID: 22200539 Free PMC article. Review.
Disease-associated polyglutamine stretches in monomeric huntingtin adopt a compact structure.
Peters-Libeu C, Miller J, Rutenber E, Newhouse Y, Krishnan P, Cheung K, Hatters D, Brooks E, Widjaja K, Tran T, Mitra S, Arrasate M, Mosquera LA, Taylor D, Weisgraber KH, Finkbeiner S. Peters-Libeu C, et al. Among authors: finkbeiner s. J Mol Biol. 2012 Aug 24;421(4-5):587-600. doi: 10.1016/j.jmb.2012.01.034. Epub 2012 Jan 28. J Mol Biol. 2012. PMID: 22306738 Free PMC article.
Identifying polyglutamine protein species in situ that best predict neurodegeneration.
Miller J, Arrasate M, Brooks E, Libeu CP, Legleiter J, Hatters D, Curtis J, Cheung K, Krishnan P, Mitra S, Widjaja K, Shaby BA, Lotz GP, Newhouse Y, Mitchell EJ, Osmand A, Gray M, Thulasiramin V, Saudou F, Segal M, Yang XW, Masliah E, Thompson LM, Muchowski PJ, Weisgraber KH, Finkbeiner S. Miller J, et al. Among authors: finkbeiner s. Nat Chem Biol. 2011 Oct 30;7(12):925-34. doi: 10.1038/nchembio.694. Nat Chem Biol. 2011. PMID: 22037470 Free PMC article.
IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome.
Thompson LM, Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, Martinez-Vincente M, Arrasate M, O'Rourke JG, Khashwji H, Lukacsovich T, Zhu YZ, Lau AL, Massey A, Hayden MR, Zeitlin SO, Finkbeiner S, Green KN, LaFerla FM, Bates G, Huang L, Patterson PH, Lo DC, Cuervo AM, Marsh JL, Steffan JS. Thompson LM, et al. Among authors: finkbeiner s. J Cell Biol. 2009 Dec 28;187(7):1083-99. doi: 10.1083/jcb.200909067. Epub 2009 Dec 21. J Cell Biol. 2009. PMID: 20026656 Free PMC article.
Huntington's Disease.
Finkbeiner S. Finkbeiner S. Cold Spring Harb Perspect Biol. 2011 Jun 1;3(6):a007476. doi: 10.1101/cshperspect.a007476. Cold Spring Harb Perspect Biol. 2011. PMID: 21441583 Free PMC article. Review.
231 results