Pick E - Search Results

1

Rational design of small molecule inhibitors targeting the Rac GTPase-p67(phox) signaling axis in inflammation.

Bosco EE, Kumar S, Marchioni F, Biesiada J, Kordos M, Szczur K, Meller J, Seibel W, Mizrahi A, Pick E, Filippi MD, Zheng Y. Bosco EE, et al. Among authors: pick e. Chem Biol. 2012 Feb 24;19(2):228-42. doi: 10.1016/j.chembiol.2011.12.017. Chem Biol. 2012. PMID: 22365606 Free PMC article.

2

Activation of the phagocyte NADPH oxidase by Rac Guanine nucleotide exchange factors in conjunction with ATP and nucleoside diphosphate kinase.

Mizrahi A, Molshanski-Mor S, Weinbaum C, Zheng Y, Hirshberg M, Pick E. Mizrahi A, et al. Among authors: pick e. J Biol Chem. 2005 Feb 4;280(5):3802-11. doi: 10.1074/jbc.M410257200. Epub 2004 Nov 19. J Biol Chem. 2005. PMID: 15557278 Free article.

3

A prenylated p47phox-p67phox-Rac1 chimera is a Quintessential NADPH oxidase activator: membrane association and functional capacity.

Mizrahi A, Berdichevsky Y, Casey PJ, Pick E. Mizrahi A, et al. Among authors: pick e. J Biol Chem. 2010 Aug 13;285(33):25485-99. doi: 10.1074/jbc.M110.113779. Epub 2010 Jun 7. J Biol Chem. 2010. PMID: 20529851 Free PMC article.

We described the construction of a tripartite chimera (trimera) consisting of strategic domains of p47(phox), p67(phox), and Rac1, in which interactions among cytosolic components were replaced by fusion (Berdichevsky, Y., Mizrahi, A., Ugolev, Y., Molshanski-Mor, S., and Pick …

We described the construction of a tripartite chimera (trimera) consisting of strategic domains of p47(phox), p67(phox), and Rac1, in which …

4

Tripartite chimeras comprising functional domains derived from the cytosolic NADPH oxidase components p47phox, p67phox, and Rac1 elicit activator-independent superoxide production by phagocyte membranes: an essential role for anionic membrane phospholipids.

Berdichevsky Y, Mizrahi A, Ugolev Y, Molshanski-Mor S, Pick E. Berdichevsky Y, et al. Among authors: pick e. J Biol Chem. 2007 Jul 27;282(30):22122-39. doi: 10.1074/jbc.M701497200. Epub 2007 Jun 4. J Biol Chem. 2007. PMID: 17548354 Free article.

5

Dual role of Rac in the assembly of NADPH oxidase, tethering to the membrane and activation of p67phox: a study based on mutagenesis of p67phox-Rac1 chimeras.

Sarfstein R, Gorzalczany Y, Mizrahi A, Berdichevsky Y, Molshanski-Mor S, Weinbaum C, Hirshberg M, Dagher MC, Pick E. Sarfstein R, et al. Among authors: pick e. J Biol Chem. 2004 Apr 16;279(16):16007-16. doi: 10.1074/jbc.M312394200. Epub 2004 Feb 3. J Biol Chem. 2004. PMID: 14761978 Free article.

6

The guanine nucleotide exchange factor trio activates the phagocyte NADPH oxidase in the absence of GDP to GTP exchange on Rac. "The emperor's nw clothes".

Sigal N, Gorzalczany Y, Sarfstein R, Weinbaum C, Zheng Y, Pick E. Sigal N, et al. Among authors: pick e. J Biol Chem. 2003 Feb 14;278(7):4854-61. doi: 10.1074/jbc.M211011200. Epub 2002 Dec 9. J Biol Chem. 2003. PMID: 12475976 Free article.

7

Assembly of the phagocyte NADPH oxidase complex: chimeric constructs derived from the cytosolic components as tools for exploring structure-function relationships.

Mizrahi A, Berdichevsky Y, Ugolev Y, Molshanski-Mor S, Nakash Y, Dahan I, Alloul N, Gorzalczany Y, Sarfstein R, Hirshberg M, Pick E. Mizrahi A, et al. Among authors: pick e. J Leukoc Biol. 2006 May;79(5):881-95. doi: 10.1189/jlb.1005553. J Leukoc Biol. 2006. PMID: 16641134 Review.

8

Cell-free assays: the reductionist approach to the study of NADPH oxidase assembly, or "all you wanted to know about cell-free assays but did not dare to ask".

Molshanski-Mor S, Mizrahi A, Ugolev Y, Dahan I, Berdichevsky Y, Pick E. Molshanski-Mor S, et al. Among authors: pick e. Methods Mol Biol. 2007;412:385-428. doi: 10.1007/978-1-59745-467-4_25. Methods Mol Biol. 2007. PMID: 18453125

9

The molecular basis of Rac-GTP action-promoting binding of p67^phox to Nox2 by disengaging the β hairpin from downstream residues.

Bechor E, Zahavi A, Berdichevsky Y, Pick E. Bechor E, et al. Among authors: pick e. J Leukoc Biol. 2021 Aug;110(2):219-237. doi: 10.1002/JLB.4HI1220-855RR. Epub 2021 Apr 15. J Leukoc Biol. 2021. PMID: 33857329

10

Role of the Rho GTPase Rac in the activation of the phagocyte NADPH oxidase: outsourcing a key task.

Pick E. Pick E. Small GTPases. 2014;5:e27952. doi: 10.4161/sgtp.27952. Epub 2014 Mar 5. Small GTPases. 2014. PMID: 24598074 Free PMC article. Review.

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