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Tyrosine phosphatase SHP2 promotes breast cancer progression and maintains tumor-initiating cells via activation of key transcription factors and a positive feedback signaling loop.
Aceto N, Sausgruber N, Brinkhaus H, Gaidatzis D, Martiny-Baron G, Mazzarol G, Confalonieri S, Quarto M, Hu G, Balwierz PJ, Pachkov M, Elledge SJ, van Nimwegen E, Stadler MB, Bentires-Alj M. Aceto N, et al. Among authors: mazzarol g. Nat Med. 2012 Mar 4;18(4):529-37. doi: 10.1038/nm.2645. Nat Med. 2012. PMID: 22388088
Memo is a copper-dependent redox protein with an essential role in migration and metastasis.
MacDonald G, Nalvarte I, Smirnova T, Vecchi M, Aceto N, Dolemeyer A, Frei A, Lienhard S, Wyckoff J, Hess D, Seebacher J, Keusch JJ, Gut H, Salaun D, Mazzarol G, Disalvatore D, Bentires-Alj M, Di Fiore PP, Badache A, Hynes NE. MacDonald G, et al. Among authors: mazzarol g. Sci Signal. 2014 Jun 10;7(329):ra56. doi: 10.1126/scisignal.2004870. Sci Signal. 2014. PMID: 24917593 Clinical Trial.
Reciprocal repression between P53 and TCTP.
Amson R, Pece S, Lespagnol A, Vyas R, Mazzarol G, Tosoni D, Colaluca I, Viale G, Rodrigues-Ferreira S, Wynendaele J, Chaloin O, Hoebeke J, Marine JC, Di Fiore PP, Telerman A. Amson R, et al. Among authors: mazzarol g. Nat Med. 2011 Dec 11;18(1):91-9. doi: 10.1038/nm.2546. Nat Med. 2011. PMID: 22157679
A RAB5/RAB4 recycling circuitry induces a proteolytic invasive program and promotes tumor dissemination.
Frittoli E, Palamidessi A, Marighetti P, Confalonieri S, Bianchi F, Malinverno C, Mazzarol G, Viale G, Martin-Padura I, Garré M, Parazzoli D, Mattei V, Cortellino S, Bertalot G, Di Fiore PP, Scita G. Frittoli E, et al. Among authors: mazzarol g. J Cell Biol. 2014 Jul 21;206(2):307-28. doi: 10.1083/jcb.201403127. J Cell Biol. 2014. PMID: 25049275 Free PMC article.
Endothelial deficiency of L1 reduces tumor angiogenesis and promotes vessel normalization.
Magrini E, Villa A, Angiolini F, Doni A, Mazzarol G, Rudini N, Maddaluno L, Komuta M, Topal B, Prenen H, Schachner M, Confalonieri S, Dejana E, Bianchi F, Mazzone M, Cavallaro U. Magrini E, et al. Among authors: mazzarol g. J Clin Invest. 2014 Oct;124(10):4335-50. doi: 10.1172/JCI70683. Epub 2014 Aug 26. J Clin Invest. 2014. PMID: 25157817 Free PMC article.
115 results