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Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.
Lacivita E, Patarnello D, Stroth N, Caroli A, Niso M, Contino M, De Giorgio P, Di Pilato P, Colabufo NA, Berardi F, Perrone R, Svenningsson P, Hedlund PB, Leopoldo M. Lacivita E, et al. Among authors: de giorgio p. J Med Chem. 2012 Jul 26;55(14):6375-80. doi: 10.1021/jm3003679. Epub 2012 Jul 11. J Med Chem. 2012. PMID: 22738316
Design, synthesis, radiolabeling, and in vivo evaluation of carbon-11 labeled N-[2-[4-(3-cyanopyridin-2-yl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a potential positron emission tomography tracer for the dopamine D(4) receptors.
Lacivita E, De Giorgio P, Lee IT, Rodeheaver SI, Weiss BA, Fracasso C, Caccia S, Berardi F, Perrone R, Zhang MR, Maeda J, Higuchi M, Suhara T, Schetz JA, Leopoldo M. Lacivita E, et al. Among authors: de giorgio p. J Med Chem. 2010 Oct 28;53(20):7344-55. doi: 10.1021/jm100925m. J Med Chem. 2010. PMID: 20873719 Free PMC article.
The therapeutic potential of 5-HT1A receptors: a patent review.
Lacivita E, Di Pilato P, De Giorgio P, Colabufo NA, Berardi F, Perrone R, Leopoldo M. Lacivita E, et al. Among authors: de giorgio p. Expert Opin Ther Pat. 2012 Aug;22(8):887-902. doi: 10.1517/13543776.2012.703654. Epub 2012 Jul 13. Expert Opin Ther Pat. 2012. PMID: 22788968 Review.
15 results