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Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes.
Yoshida T, Akahoshi F, Sakashita H, Kitajima H, Nakamura M, Sonda S, Takeuchi M, Tanaka Y, Ueda N, Sekiguchi S, Ishige T, Shima K, Nabeno M, Abe Y, Anabuki J, Soejima A, Yoshida K, Takashina Y, Ishii S, Kiuchi S, Fukuda S, Tsutsumiuchi R, Kosaka K, Murozono T, Nakamaru Y, Utsumi H, Masutomi N, Kishida H, Miyaguchi I, Hayashi Y. Yoshida T, et al. Among authors: kishida h. Bioorg Med Chem. 2012 Oct 1;20(19):5705-19. doi: 10.1016/j.bmc.2012.08.012. Epub 2012 Aug 17. Bioorg Med Chem. 2012. PMID: 22959556
Transport and inhibition mechanism of the human SGLT2-MAP17 glucose transporter.
Hiraizumi M, Akashi T, Murasaki K, Kishida H, Kumanomidou T, Torimoto N, Nureki O, Miyaguchi I. Hiraizumi M, et al. Among authors: kishida h. Nat Struct Mol Biol. 2024 Jan;31(1):159-169. doi: 10.1038/s41594-023-01134-0. Epub 2023 Dec 6. Nat Struct Mol Biol. 2024. PMID: 38057552 Free PMC article.
A method for delivering the required neutron fluence in an accelerator-based boron neutron capture therapy system employing a lithium target.
Nakamura S, Takemori M, Nakaichi T, Shuto Y, Kashihara T, Iijima K, Chiba T, Nakayama H, Urago Y, Nishina S, Kobayashi Y, Kishida H, Imamichi S, Takahashi K, Masutani M, Okamoto H, Nishio T, Itami J, Igaki H. Nakamura S, et al. Among authors: kishida h. Sci Rep. 2024 May 16;14(1):11253. doi: 10.1038/s41598-024-62060-9. Sci Rep. 2024. PMID: 38755333 Free PMC article.
302 results