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Akt phosphorylates the transcriptional repressor bmi1 to block its effects on the tumor-suppressing ink4a-arf locus.
Liu Y, Liu F, Yu H, Zhao X, Sashida G, Deblasio A, Harr M, She QB, Chen Z, Lin HK, Di Giandomenico S, Elf SE, Yang Y, Miyata Y, Huang G, Menendez S, Mellinghoff IK, Rosen N, Pandolfi PP, Hedvat CV, Nimer SD. Liu Y, et al. Among authors: she qb. Sci Signal. 2012 Oct 23;5(247):ra77. doi: 10.1126/scisignal.2003199. Sci Signal. 2012. PMID: 23092893 Free PMC article.
AKT and cancer--is it all mTOR?
Rosen N, She QB. Rosen N, et al. Among authors: she qb. Cancer Cell. 2006 Oct;10(4):254-6. doi: 10.1016/j.ccr.2006.10.001. Cancer Cell. 2006. PMID: 17045203 Free article.
Genomic complexity and AKT dependence in serous ovarian cancer.
Hanrahan AJ, Schultz N, Westfal ML, Sakr RA, Giri DD, Scarperi S, Janakiraman M, Olvera N, Stevens EV, She QB, Aghajanian C, King TA, Stanchina Ed, Spriggs DR, Heguy A, Taylor BS, Sander C, Rosen N, Levine DA, Solit DB. Hanrahan AJ, et al. Among authors: she qb. Cancer Discov. 2012 Jan;2(1):56-67. doi: 10.1158/2159-8290.CD-11-0170. Cancer Discov. 2012. PMID: 22328975 Free PMC article.
Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity.
Saal LH, Johansson P, Holm K, Gruvberger-Saal SK, She QB, Maurer M, Koujak S, Ferrando AA, Malmström P, Memeo L, Isola J, Bendahl PO, Rosen N, Hibshoosh H, Ringnér M, Borg A, Parsons R. Saal LH, et al. Among authors: she qb. Proc Natl Acad Sci U S A. 2007 May 1;104(18):7564-9. doi: 10.1073/pnas.0702507104. Epub 2007 Apr 23. Proc Natl Acad Sci U S A. 2007. PMID: 17452630 Free PMC article.
54 results