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Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2).
Nagano JM, Hsu KL, Whitby LR, Niphakis MJ, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Hodder P, Srinivasan P, Gonzalez TD, Rosen H, Bahnson BJ, Cravatt BF. Nagano JM, et al. Among authors: hodder p. Bioorg Med Chem Lett. 2013 Feb 1;23(3):839-43. doi: 10.1016/j.bmcl.2012.11.061. Epub 2012 Dec 2. Bioorg Med Chem Lett. 2013. PMID: 23260346 Free PMC article.
Ligand-binding pocket shape differences between sphingosine 1-phosphate (S1P) receptors S1P1 and S1P3 determine efficiency of chemical probe identification by ultrahigh-throughput screening.
Schürer SC, Brown SJ, Gonzalez-Cabrera PJ, Schaeffer MT, Chapman J, Jo E, Chase P, Spicer T, Hodder P, Rosen H. Schürer SC, et al. Among authors: hodder p. ACS Chem Biol. 2008 Aug 15;3(8):486-98. doi: 10.1021/cb800051m. Epub 2008 Jul 1. ACS Chem Biol. 2008. PMID: 18590333 Free PMC article.
Reversible inhibitor of p97, DBeQ, impairs both ubiquitin-dependent and autophagic protein clearance pathways.
Chou TF, Brown SJ, Minond D, Nordin BE, Li K, Jones AC, Chase P, Porubsky PR, Stoltz BM, Schoenen FJ, Patricelli MP, Hodder P, Rosen H, Deshaies RJ. Chou TF, et al. Among authors: hodder p. Proc Natl Acad Sci U S A. 2011 Mar 22;108(12):4834-9. doi: 10.1073/pnas.1015312108. Epub 2011 Mar 7. Proc Natl Acad Sci U S A. 2011. PMID: 21383145 Free PMC article.
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.
Bachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Schürer SC, Nomura DK, Rosen H, Fu GC, Cravatt BF. Bachovchin DA, et al. Among authors: hodder ps. Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6811-6. doi: 10.1073/pnas.1015248108. Epub 2011 Mar 11. Proc Natl Acad Sci U S A. 2011. PMID: 21398589 Free PMC article.
152 results