Fauq AH - Search Results

1

Optimization of peptide hydroxamate inhibitors of insulin-degrading enzyme reveals marked substrate-selectivity.

Abdul-Hay SO, Lane AL, Caulfield TR, Claussin C, Bertrand J, Masson A, Choudhry S, Fauq AH, Maharvi GM, Leissring MA. Abdul-Hay SO, et al. Among authors: fauq ah. J Med Chem. 2013 Mar 28;56(6):2246-55. doi: 10.1021/jm301280p. Epub 2013 Mar 15. J Med Chem. 2013. PMID: 23437776 Free PMC article.

2

Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.

Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, Manolopoulou M, Tang WJ, Stein RL, Cuny GD, Selkoe DJ. Leissring MA, et al. Among authors: fauq ah. PLoS One. 2010 May 7;5(5):e10504. doi: 10.1371/journal.pone.0010504. PLoS One. 2010. PMID: 20498699 Free PMC article.

3

A multigram chemical synthesis of the gamma-secretase inhibitor LY411575 and its diastereoisomers.

Fauq AH, Simpson K, Maharvi GM, Golde T, Das P. Fauq AH, et al. Bioorg Med Chem Lett. 2007 Nov 15;17(22):6392-5. doi: 10.1016/j.bmcl.2007.07.062. Epub 2007 Aug 30. Bioorg Med Chem Lett. 2007. PMID: 17897827 Free PMC article.

4

Deoxygenated inositol 1,4,5-trisphosphate analogues and their interaction with metabolic enzymes. (1R,2R,4R)-cyclohexane-1,2,4-tris(methylenesulfonate): a potent selective 5-phosphatase inhibitor.

Kozikowski AP, Ognyanov VI, Chen C, Fauq AH, Safrany ST, Wilcox RA, Nahorski SR. Kozikowski AP, et al. Among authors: fauq ah. J Med Chem. 1993 Oct 1;36(20):3035-8. doi: 10.1021/jm00072a027. J Med Chem. 1993. PMID: 8411022 No abstract available.

5

Regulation of steady-state beta-amyloid levels in the brain by neprilysin and endothelin-converting enzyme but not angiotensin-converting enzyme.

Eckman EA, Adams SK, Troendle FJ, Stodola BA, Kahn MA, Fauq AH, Xiao HD, Bernstein KE, Eckman CB. Eckman EA, et al. Among authors: fauq ah. J Biol Chem. 2006 Oct 13;281(41):30471-8. doi: 10.1074/jbc.M605827200. Epub 2006 Aug 14. J Biol Chem. 2006. PMID: 16912050 Free article.

6

A convenient synthesis of (Z)-4-hydroxy-N-desmethyltamoxifen (endoxifen).

Fauq AH, Maharvi GM, Sinha D. Fauq AH, et al. Bioorg Med Chem Lett. 2010 May 15;20(10):3036-8. doi: 10.1016/j.bmcl.2010.03.117. Epub 2010 Apr 3. Bioorg Med Chem Lett. 2010. PMID: 20400308

7

The novel Ins(1,4,5)P3 analogue 3-amino-3-deoxy-Ins(1,4,5)P3: a pH-dependent Ins(1,4,5)P3 receptor partial agonist in SH-SY5Y neuroblastoma cells.

Kozikowski AP, Fauq AH, Wilcox RA, Challiss RA, Nahorski SR. Kozikowski AP, et al. Among authors: fauq ah. J Med Chem. 1994 Mar 18;37(6):868-72. doi: 10.1021/jm00032a022. J Med Chem. 1994. PMID: 8145238

8

Synthesis of a DOTA (Gd3+)-conjugate of proton-pump inhibitor pantoprazole for gastric wall imaging studies.

Maharvi GM, Bharucha AE, Fauq AH. Maharvi GM, et al. Among authors: fauq ah. Bioorg Med Chem Lett. 2013 May 1;23(9):2808-11. doi: 10.1016/j.bmcl.2012.06.051. Epub 2012 Jun 23. Bioorg Med Chem Lett. 2013. PMID: 23511016 Free PMC article.

9

Substrate-targeting gamma-secretase modulators.

Kukar TL, Ladd TB, Bann MA, Fraering PC, Narlawar R, Maharvi GM, Healy B, Chapman R, Welzel AT, Price RW, Moore B, Rangachari V, Cusack B, Eriksen J, Jansen-West K, Verbeeck C, Yager D, Eckman C, Ye W, Sagi S, Cottrell BA, Torpey J, Rosenberry TL, Fauq A, Wolfe MS, Schmidt B, Walsh DM, Koo EH, Golde TE. Kukar TL, et al. Nature. 2008 Jun 12;453(7197):925-9. doi: 10.1038/nature07055. Nature. 2008. PMID: 18548070 Free PMC article.

10

Pharmacological and biochemical profiles of unique neurotensin 8-13 analogs exhibiting species selectivity, stereoselectivity, and superagonism.

Cusack B, McCormick DJ, Pang YP, Souder T, Garcia R, Fauq A, Richelson E. Cusack B, et al. J Biol Chem. 1995 Aug 4;270(31):18359-66. doi: 10.1074/jbc.270.31.18359. J Biol Chem. 1995. PMID: 7629159 Free article.

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