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Hydrolysis of low concentrations of the acetylthiocholine analogs acetyl(homo)thiocholine and acetyl(nor)thiocholine by acetylcholinesterase may be limited by selective gating at the enzyme peripheral site.
Beri V, Auletta JT, Maharvi GM, Wood JF, Fauq AH, Rosenberry TL. Beri V, et al. Among authors: maharvi gm. Chem Biol Interact. 2013 Mar 25;203(1):38-43. doi: 10.1016/j.cbi.2012.09.017. Epub 2012 Oct 6. Chem Biol Interact. 2013. PMID: 23047027 Free PMC article.
Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin.
Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, Manolopoulou M, Tang WJ, Stein RL, Cuny GD, Selkoe DJ. Leissring MA, et al. Among authors: maharvi gm. PLoS One. 2010 May 7;5(5):e10504. doi: 10.1371/journal.pone.0010504. PLoS One. 2010. PMID: 20498699 Free PMC article.
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