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Succinate is an inflammatory signal that induces IL-1β through HIF-1α.
Tannahill GM, Curtis AM, Adamik J, Palsson-McDermott EM, McGettrick AF, Goel G, Frezza C, Bernard NJ, Kelly B, Foley NH, Zheng L, Gardet A, Tong Z, Jany SS, Corr SC, Haneklaus M, Caffrey BE, Pierce K, Walmsley S, Beasley FC, Cummins E, Nizet V, Whyte M, Taylor CT, Lin H, Masters SL, Gottlieb E, Kelly VP, Clish C, Auron PE, Xavier RJ, O'Neill LA. Tannahill GM, et al. Among authors: whyte m. Nature. 2013 Apr 11;496(7444):238-42. doi: 10.1038/nature11986. Epub 2013 Mar 24. Nature. 2013. PMID: 23535595 Free PMC article.
The HIF/VHL pathway: from oxygen sensing to innate immunity.
Walmsley SR, McGovern NN, Whyte MK, Chilvers ER. Walmsley SR, et al. Am J Respir Cell Mol Biol. 2008 Mar;38(3):251-5. doi: 10.1165/rcmb.2007-0331TR. Epub 2007 Oct 11. Am J Respir Cell Mol Biol. 2008. PMID: 17932373 Review.
Neutrophil energetics and oxygen sensing.
Walmsley SR, Whyte MK. Walmsley SR, et al. Blood. 2014 May 1;123(18):2753-4. doi: 10.1182/blood-2014-03-560409. Blood. 2014. PMID: 24786455 Free article.
Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.
Sadiku P, Willson JA, Dickinson RS, Murphy F, Harris AJ, Lewis A, Sammut D, Mirchandani AS, Ryan E, Watts ER, Thompson AAR, Marriott HM, Dockrell DH, Taylor CT, Schneider M, Maxwell PH, Chilvers ER, Mazzone M, Moral V, Pugh CW, Ratcliffe PJ, Schofield CJ, Ghesquiere B, Carmeliet P, Whyte MK, Walmsley SR. Sadiku P, et al. Among authors: whyte mk. J Clin Invest. 2017 Sep 1;127(9):3407-3420. doi: 10.1172/JCI90848. Epub 2017 Aug 14. J Clin Invest. 2017. PMID: 28805660 Free PMC article.
723 results