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Biodistribution of the GATA-3-specific DNAzyme hgd40 after inhalative exposure in mice, rats and dogs.
Toxicol Appl Pharmacol. 2013 Oct 15;272(2):365-72. doi: 10.1016/j.taap.2013.06.020. Epub 2013 Jun 29.
Toxicol Appl Pharmacol. 2013.
PMID: 23820074
Allergen-induced asthmatic responses modified by a GATA3-specific DNAzyme.
Krug N, Hohlfeld JM, Kirsten AM, Kornmann O, Beeh KM, Kappeler D, Korn S, Ignatenko S, Timmer W, Rogon C, Zeitvogel J, Zhang N, Bille J, Homburg U, Turowska A, Bachert C, Werfel T, Buhl R, Renz J, Garn H, Renz H.
Krug N, et al. Among authors: homburg u.
N Engl J Med. 2015 May 21;372(21):1987-95. doi: 10.1056/NEJMoa1411776. Epub 2015 May 17.
N Engl J Med. 2015.
PMID: 25981191
Free article.
Clinical Trial.
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Safety and tolerability of a novel inhaled GATA3 mRNA targeting DNAzyme in patients with TH2-driven asthma.
Homburg U, Renz H, Timmer W, Hohlfeld JM, Seitz F, Lüer K, Mayer A, Wacker A, Schmidt O, Kuhlmann J, Turowska A, Roller J, Kutz K, Schlüter G, Krug N, Garn H.
Homburg U, et al.
J Allergy Clin Immunol. 2015 Sep;136(3):797-800. doi: 10.1016/j.jaci.2015.02.018. Epub 2015 Apr 2.
J Allergy Clin Immunol. 2015.
PMID: 25842286
Clinical Trial.
No abstract available.
Item in Clipboard
A GATA3-specific DNAzyme attenuates sputum eosinophilia in eosinophilic COPD patients: a feasibility randomized clinical trial.
Greulich T, Hohlfeld JM, Neuser P, Lueer K, Klemmer A, Schade-Brittinger C, Harnisch S, Garn H, Renz H, Homburg U, Renz J, Kirsten A, Pedersen F, Müller M, Vogelmeier CF, Watz H.
Greulich T, et al. Among authors: homburg u.
Respir Res. 2018 Apr 4;19(1):55. doi: 10.1186/s12931-018-0751-x.
Respir Res. 2018.
PMID: 29615049
Free PMC article.
Clinical Trial.
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