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The β-arrestin-biased ligand TRV120023 inhibits angiotensin II-induced cardiac hypertrophy while preserving enhanced myofilament response to calcium.
Monasky MM, Taglieri DM, Henze M, Warren CM, Utter MS, Soergel DG, Violin JD, Solaro RJ. Monasky MM, et al. Among authors: soergel dg. Am J Physiol Heart Circ Physiol. 2013 Sep 15;305(6):H856-66. doi: 10.1152/ajpheart.00327.2013. Epub 2013 Jul 19. Am J Physiol Heart Circ Physiol. 2013. PMID: 23873795 Free PMC article.
Heart failure therapeutics on the basis of a biased ligand of the angiotensin-2 type 1 receptor. Rationale and design of the BLAST-AHF study (Biased Ligand of the Angiotensin Receptor Study in Acute Heart Failure).
Felker GM, Butler J, Collins SP, Cotter G, Davison BA, Ezekowitz JA, Filippatos G, Levy PD, Metra M, Ponikowski P, Soergel DG, Teerlink JR, Violin JD, Voors AA, Pang PS. Felker GM, et al. Among authors: soergel dg. JACC Heart Fail. 2015 Mar;3(3):193-201. doi: 10.1016/j.jchf.2014.09.008. Epub 2015 Jan 28. JACC Heart Fail. 2015. PMID: 25650371 Free article. Review.
GPCR biased ligands as novel heart failure therapeutics.
Violin JD, Soergel DG, Boerrigter G, Burnett JC Jr, Lark MW. Violin JD, et al. Among authors: soergel dg. Trends Cardiovasc Med. 2013 Oct;23(7):242-9. doi: 10.1016/j.tcm.2013.01.002. Epub 2013 Mar 15. Trends Cardiovasc Med. 2013. PMID: 23499300 Review.
Biased agonism of the μ-opioid receptor by TRV130 increases analgesia and reduces on-target adverse effects versus morphine: A randomized, double-blind, placebo-controlled, crossover study in healthy volunteers.
Soergel DG, Subach RA, Burnham N, Lark MW, James IE, Sadler BM, Skobieranda F, Violin JD, Webster LR. Soergel DG, et al. Pain. 2014 Sep;155(9):1829-1835. doi: 10.1016/j.pain.2014.06.011. Epub 2014 Jun 19. Pain. 2014. PMID: 24954166 Clinical Trial.
Biased ligand of the angiotensin II type 1 receptor in patients with acute heart failure: a randomized, double-blind, placebo-controlled, phase IIB, dose ranging trial (BLAST-AHF).
Pang PS, Butler J, Collins SP, Cotter G, Davison BA, Ezekowitz JA, Filippatos G, Levy PD, Metra M, Ponikowski P, Teerlink JR, Voors AA, Bharucha D, Goin K, Soergel DG, Felker GM. Pang PS, et al. Among authors: soergel dg. Eur Heart J. 2017 Aug 7;38(30):2364-2373. doi: 10.1093/eurheartj/ehx196. Eur Heart J. 2017. PMID: 28459958 Free PMC article. Clinical Trial.
27 results