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ENU-induced mutation in the DNA-binding domain of KLF3 reveals important roles for KLF3 in cardiovascular development and function in mice.
Kelsey L, Flenniken AM, Qu D, Funnell AP, Pearson R, Zhou YQ, Voronina I, Berberovic Z, Wood G, Newbigging S, Weiss ES, Wong M, Quach I, Yeh SY, Deshwar AR, Scott IC, McKerlie C, Henkelman M, Backx P, Simpson J, Osborne L, Rossant J, Crossley M, Bruneau B, Adamson SL. Kelsey L, et al. Among authors: osborne l. PLoS Genet. 2013;9(7):e1003612. doi: 10.1371/journal.pgen.1003612. Epub 2013 Jul 11. PLoS Genet. 2013. PMID: 23874215 Free PMC article.
A Gja1 missense mutation in a mouse model of oculodentodigital dysplasia.
Flenniken AM, Osborne LR, Anderson N, Ciliberti N, Fleming C, Gittens JE, Gong XQ, Kelsey LB, Lounsbury C, Moreno L, Nieman BJ, Peterson K, Qu D, Roscoe W, Shao Q, Tong D, Veitch GI, Voronina I, Vukobradovic I, Wood GA, Zhu Y, Zirngibl RA, Aubin JE, Bai D, Bruneau BG, Grynpas M, Henderson JE, Henkelman RM, McKerlie C, Sled JG, Stanford WL, Laird DW, Kidder GM, Adamson SL, Rossant J. Flenniken AM, et al. Among authors: osborne lr. Development. 2005 Oct;132(19):4375-86. doi: 10.1242/dev.02011. Development. 2005. PMID: 16155213
Cytopenia induction by 5-fluorouracil identifies thrombopoietic mutants in sensitized ENU mutagenesis screens.
Anderson NM, Berberovic Z, Berndl E, Bailey ML, Flenniken AM, Osborne LR, Adamson SL, Rossant J, Wang C, Minden MD, McNagny KM, Paulson RF, Barber DL, Stanford WL. Anderson NM, et al. Among authors: osborne lr. Exp Hematol. 2012 Jan;40(1):48-60. doi: 10.1016/j.exphem.2011.09.007. Epub 2011 Sep 14. Exp Hematol. 2012. PMID: 21924221 Free PMC article.
Enu mutagenesis identifies a novel platelet phenotype in a loss-of-function Jak2 allele.
Anderson NM, Javadi M, Berndl E, Berberovic Z, Bailey ML, Huang K, Flenniken AM, Osborne LR, Adamson SL, Rossant J, Carter-Su C, Wang C, McNagny KM, Paulson RF, Minden MD, Stanford WL, Barber DL. Anderson NM, et al. Among authors: osborne lr. PLoS One. 2013 Sep 25;8(9):e75472. doi: 10.1371/journal.pone.0075472. eCollection 2013. PLoS One. 2013. PMID: 24086539 Free PMC article.
A novel ENU-generated truncation mutation lacking the spectrin-binding and C-terminal regulatory domains of Ank1 models severe hemolytic hereditary spherocytosis.
Hughes MR, Anderson N, Maltby S, Wong J, Berberovic Z, Birkenmeier CS, Haddon DJ, Garcha K, Flenniken A, Osborne LR, Adamson SL, Rossant J, Peters LL, Minden MD, Paulson RF, Wang C, Barber DL, McNagny KM, Stanford WL. Hughes MR, et al. Among authors: osborne lr. Exp Hematol. 2011 Mar;39(3):305-20, 320.e1-2. doi: 10.1016/j.exphem.2010.12.009. Epub 2010 Dec 28. Exp Hematol. 2011. PMID: 21193012 Free PMC article.
The Sweet Pee model for Sglt2 mutation.
Ly JP, Onay T, Sison K, Sivaskandarajah G, Sabbisetti V, Li L, Bonventre JV, Flenniken A, Paragas N, Barasch JM, Adamson SL, Osborne L, Rossant J, Schnermann J, Quaggin SE. Ly JP, et al. Among authors: osborne l. J Am Soc Nephrol. 2011 Jan;22(1):113-23. doi: 10.1681/ASN.2010080888. J Am Soc Nephrol. 2011. PMID: 21209254 Free PMC article.
First mouse model for combined osteogenesis imperfecta and Ehlers-Danlos syndrome.
Chen F, Guo R, Itoh S, Moreno L, Rosenthal E, Zappitelli T, Zirngibl RA, Flenniken A, Cole W, Grynpas M, Osborne LR, Vogel W, Adamson L, Rossant J, Aubin JE. Chen F, et al. Among authors: osborne lr. J Bone Miner Res. 2014 Jun;29(6):1412-23. doi: 10.1002/jbmr.2177. J Bone Miner Res. 2014. PMID: 24443344 Free article.
511 results