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Discovery and SAR of a novel series of GIRK1/2 and GIRK1/4 activators.
Ramos-Hunter SJ, Engers DW, Kaufmann K, Du Y, Lindsley CW, Weaver CD, Sulikowski GA. Ramos-Hunter SJ, et al. Among authors: sulikowski ga. Bioorg Med Chem Lett. 2013 Sep 15;23(18):5195-8. doi: 10.1016/j.bmcl.2013.07.002. Epub 2013 Jul 18. Bioorg Med Chem Lett. 2013. PMID: 23916258 Free PMC article.
Biosynthesis of the Apoptolidins in Nocardiopsis sp. FU 40.
Du Y, Derewacz DK, Deguire SM, Teske J, Ravel J, Sulikowski GA, Bachmann BO. Du Y, et al. Among authors: sulikowski ga. Tetrahedron. 2011 Sep 2;67(35):6568-6575. doi: 10.1016/j.tet.2011.05.106. Tetrahedron. 2011. PMID: 21869849 Free PMC article.
Development of a more highly selective M(1) antagonist from the continued optimization of the MLPCN Probe ML012.
Melancon BJ, Lamers AP, Bridges TM, Sulikowski GA, Utley TJ, Sheffler DJ, Noetzel MJ, Morrison RD, Daniels JS, Niswender CM, Jones CK, Conn PJ, Lindsley CW, Wood MR. Melancon BJ, et al. Among authors: sulikowski ga. Bioorg Med Chem Lett. 2012 Jan 15;22(2):1044-8. doi: 10.1016/j.bmcl.2011.11.110. Epub 2011 Dec 6. Bioorg Med Chem Lett. 2012. PMID: 22197142 Free PMC article.
ML297 (VU0456810), the first potent and selective activator of the GIRK potassium channel, displays antiepileptic properties in mice.
Kaufmann K, Romaine I, Days E, Pascual C, Malik A, Yang L, Zou B, Du Y, Sliwoski G, Morrison RD, Denton J, Niswender CM, Daniels JS, Sulikowski GA, Xie XS, Lindsley CW, Weaver CD. Kaufmann K, et al. Among authors: sulikowski ga. ACS Chem Neurosci. 2013 Sep 18;4(9):1278-86. doi: 10.1021/cn400062a. Epub 2013 Jun 13. ACS Chem Neurosci. 2013. PMID: 23730969 Free PMC article.
Narrow SAR in odorant sensing Orco receptor agonists.
Romaine IM, Taylor RW, Saidu SP, Kim K, Sulikowski GA, Zwiebel LJ, Waterson AG. Romaine IM, et al. Among authors: sulikowski ga. Bioorg Med Chem Lett. 2014 Jun 15;24(12):2613-6. doi: 10.1016/j.bmcl.2014.04.081. Epub 2014 Apr 29. Bioorg Med Chem Lett. 2014. PMID: 24813736 Free PMC article.
98 results