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Exploring natural product chemistry and biology with multicomponent reactions. 5. Discovery of a novel tubulin-targeting scaffold derived from the rigidin family of marine alkaloids.
Frolova LV, Magedov IV, Romero AE, Karki M, Otero I, Hayden K, Evdokimov NM, Banuls LM, Rastogi SK, Smith WR, Lu SL, Kiss R, Shuster CB, Hamel E, Betancourt T, Rogelj S, Kornienko A. Frolova LV, et al. Among authors: kiss r. J Med Chem. 2013 Sep 12;56(17):6886-900. doi: 10.1021/jm400711t. Epub 2013 Aug 23. J Med Chem. 2013. PMID: 23927793 Free PMC article.
Structural simplification of bioactive natural products with multicomponent synthesis. 3. Fused uracil-containing heterocycles as novel topoisomerase-targeting agents.
Evdokimov NM, Van Slambrouck S, Heffeter P, Tu L, Le Calvé B, Lamoral-Theys D, Hooten CJ, Uglinskii PY, Rogelj S, Kiss R, Steelant WF, Berger W, Yang JJ, Bologa CG, Kornienko A, Magedov IV. Evdokimov NM, et al. Among authors: kiss r. J Med Chem. 2011 Apr 14;54(7):2012-21. doi: 10.1021/jm1009428. Epub 2011 Mar 9. J Med Chem. 2011. PMID: 21388138 Free PMC article.
In search of a cytostatic agent derived from the alkaloid lycorine: synthesis and growth inhibitory properties of lycorine derivatives.
Evdokimov NM, Lamoral-Theys D, Mathieu V, Andolfi A, Frolova LV, Pelly SC, van Otterlo WA, Magedov IV, Kiss R, Evidente A, Kornienko A. Evdokimov NM, et al. Among authors: kiss r. Bioorg Med Chem. 2011 Dec 1;19(23):7252-61. doi: 10.1016/j.bmc.2011.09.051. Epub 2011 Oct 2. Bioorg Med Chem. 2011. PMID: 22019045 Free PMC article.
5,10b-Ethanophenanthridine amaryllidaceae alkaloids inspire the discovery of novel bicyclic ring systems with activity against drug resistant cancer cells.
Henry S, Kidner R, Reisenauer MR, Magedov IV, Kiss R, Mathieu V, Lefranc F, Dasari R, Evidente A, Yu X, Ma X, Pertsemlidis A, Cencic R, Pelletier J, Cavazos DA, Brenner AJ, Aksenov AV, Rogelj S, Kornienko A, Frolova LV. Henry S, et al. Among authors: kiss r. Eur J Med Chem. 2016 Sep 14;120:313-28. doi: 10.1016/j.ejmech.2016.05.004. Epub 2016 May 6. Eur J Med Chem. 2016. PMID: 27218860 Free PMC article.
Bulbispermine: a crinine-type Amaryllidaceae alkaloid exhibiting cytostatic activity toward apoptosis-resistant glioma cells.
Luchetti G, Johnston R, Mathieu V, Lefranc F, Hayden K, Andolfi A, Lamoral-Theys D, Reisenauer MR, Champion C, Pelly SC, van Otterlo WA, Magedov IV, Kiss R, Evidente A, Rogelj S, Kornienko A. Luchetti G, et al. Among authors: kiss r. ChemMedChem. 2012 May;7(5):815-22. doi: 10.1002/cmdc.201100608. Epub 2012 Mar 2. ChemMedChem. 2012. PMID: 22389235 Free PMC article.
Therapeutic agents triggering nonapoptotic cancer cell death.
Kornienko A, Mathieu V, Rastogi SK, Lefranc F, Kiss R. Kornienko A, et al. Among authors: kiss r. J Med Chem. 2013 Jun 27;56(12):4823-39. doi: 10.1021/jm400136m. Epub 2013 Apr 5. J Med Chem. 2013. PMID: 23517069 Review.
Activity of 2-aryl-2-(3-indolyl)acetohydroxamates against drug-resistant cancer cells.
Aksenov AV, Smirnov AN, Magedov IV, Reisenauer MR, Aksenov NA, Aksenova IV, Pendleton AL, Nguyen G, Johnston RK, Rubin M, De Carvalho A, Kiss R, Mathieu V, Lefranc F, Correa J, Cavazos DA, Brenner AJ, Bryan BA, Rogelj S, Kornienko A, Frolova LV. Aksenov AV, et al. Among authors: kiss r. J Med Chem. 2015 Mar 12;58(5):2206-20. doi: 10.1021/jm501518y. Epub 2015 Feb 20. J Med Chem. 2015. PMID: 25671501 Free PMC article.
Wittig derivatization of sesquiterpenoid polygodial leads to cytostatic agents with activity against drug resistant cancer cells and capable of pyrrolylation of primary amines.
Dasari R, De Carvalho A, Medellin DC, Middleton KN, Hague F, Volmar MN, Frolova LV, Rossato MF, De La Chapa JJ, Dybdal-Hargreaves NF, Pillai A, Kälin RE, Mathieu V, Rogelj S, Gonzales CB, Calixto JB, Evidente A, Gautier M, Munirathinam G, Glass R, Burth P, Pelly SC, van Otterlo WA, Kiss R, Kornienko A. Dasari R, et al. Among authors: kiss r. Eur J Med Chem. 2015 Oct 20;103:226-37. doi: 10.1016/j.ejmech.2015.08.047. Epub 2015 Aug 29. Eur J Med Chem. 2015. PMID: 26360047 Free PMC article.
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