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CDR-restricted engineering of native human scFvs creates highly stable and soluble bifunctional antibodies for subcutaneous delivery.
Fennell BJ, McDonnell B, Tam AS, Chang L, Steven J, Broadbent ID, Gao H, Kieras E, Alley J, Luxenberg D, Edmonds J, Fitz LJ, Miao W, Whitters MJ, Medley QG, Guo YJ, Darmanin-Sheehan A, Autin B, Shúilleabháin DN, Cummins E, King A, Krebs MR, Grace C, Hickling TP, Boisvert A, Zhong X, McKenna M, Francis C, Olland S, Bloom L, Paulsen J, Somers W, Jensen A, Lin L, Finlay WJ, Cunningham O. Fennell BJ, et al. Among authors: medley qg. MAbs. 2013 Nov-Dec;5(6):882-95. doi: 10.4161/mabs.26201. Epub 2013 Aug 21. MAbs. 2013. PMID: 23995618 Free PMC article.
IL-21 receptor is required for the systemic accumulation of activated B and T lymphocytes in MRL/MpJ-Fas(lpr/lpr)/J mice.
Rankin AL, Guay H, Herber D, Bertino SA, Duzanski TA, Carrier Y, Keegan S, Senices M, Stedman N, Ryan M, Bloom L, Medley Q, Collins M, Nickerson-Nutter C, Craft J, Young D, Dunussi-Joannopoulos K. Rankin AL, et al. J Immunol. 2012 Feb 15;188(4):1656-67. doi: 10.4049/jimmunol.1003871. Epub 2012 Jan 9. J Immunol. 2012. PMID: 22231702 Free PMC article.
Selectively targeting an inactive conformation of interleukin-2-inducible T-cell kinase by allosteric inhibitors.
Han S, Czerwinski RM, Caspers NL, Limburg DC, Ding W, Wang H, Ohren JF, Rajamohan F, McLellan TJ, Unwalla R, Choi C, Parikh MD, Seth N, Edmonds J, Phillips C, Shakya S, Li X, Spaulding V, Hughes S, Cook A, Robinson C, Mathias JP, Navratilova I, Medley QG, Anderson DR, Kurumbail RG, Aulabaugh A. Han S, et al. Among authors: medley qg. Biochem J. 2014 Jun 1;460(2):211-22. doi: 10.1042/BJ20131139. Biochem J. 2014. PMID: 24593284
IL-22 induces an acute-phase response.
Liang SC, Nickerson-Nutter C, Pittman DD, Carrier Y, Goodwin DG, Shields KM, Lambert AJ, Schelling SH, Medley QG, Ma HL, Collins M, Dunussi-Joannopoulos K, Fouser LA. Liang SC, et al. Among authors: medley qg. J Immunol. 2010 Nov 1;185(9):5531-8. doi: 10.4049/jimmunol.0904091. Epub 2010 Sep 24. J Immunol. 2010. PMID: 20870942
The Hierarchy of Proinflammatory Cytokines in Ocular Inflammation.
Da Cunha AP, Zhang Q, Prentiss M, Wu XQ, Kainz V, Xu YY, Vrouvlianis J, Li H, Rangaswamy N, Leehy B, McGee TL, Bell CL, Bigelow CE, Kansara V, Medley Q, Huang Q, Wu HY. Da Cunha AP, et al. Curr Eye Res. 2018 Apr;43(4):553-565. doi: 10.1080/02713683.2017.1410180. Epub 2017 Dec 4. Curr Eye Res. 2018. PMID: 29199855
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