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Discovery of 1-oxa-4,9-diazaspiro[5.5]undecane-based trisubstituted urea derivatives as highly potent soluble epoxide hydrolase inhibitors and orally active drug candidates for treating of chronic kidney diseases.
Kato Y, Fuchi N, Nishimura Y, Watanabe A, Yagi M, Nakadera Y, Higashi E, Yamada M, Aoki T, Kigoshi H. Kato Y, et al. Bioorg Med Chem Lett. 2014 Jan 15;24(2):565-70. doi: 10.1016/j.bmcl.2013.12.020. Epub 2013 Dec 10. Bioorg Med Chem Lett. 2014. PMID: 24373724
Practical synthesis and evaluation of the biological activities of 1alpha,25-dihydroxyvitamin D3 antagonists, 1alpha,25-dihydroxyvitamin D3-26,23-lactams. Designed on the basis of the helix 12-folding inhibition hypothesis.
Nakano Y, Kato Y, Imai K, Ochiai E, Namekawa J, Ishizuka S, Takenouchi K, Tanatani A, Hashimoto Y, Nagasawa K. Nakano Y, et al. Among authors: kato y. J Med Chem. 2006 Apr 20;49(8):2398-406. doi: 10.1021/jm050738x. J Med Chem. 2006. PMID: 16610783
Maintenance of R-loop structures by phosphorylated hTERT preserves genome integrity.
Machitani M, Nomura A, Yamashita T, Yasukawa M, Ueki S, Fujita KI, Ueno T, Yamashita A, Tanzawa Y, Watanabe M, Taniguchi T, Saitoh N, Kaneko S, Kato Y, Mano H, Masutomi K. Machitani M, et al. Among authors: kato y. Nat Cell Biol. 2024 May 28. doi: 10.1038/s41556-024-01427-6. Online ahead of print. Nat Cell Biol. 2024. PMID: 38806647
Serum miR‑29 is increased in mice with early liver fibrosis.
Matsumoto K, Ohsugi Y, Tayama C, Hayashi M, Kato Y, Ohashi M, Chiba M. Matsumoto K, et al. Among authors: kato y. Exp Ther Med. 2024 May 15;28(1):285. doi: 10.3892/etm.2024.12573. eCollection 2024 Jul. Exp Ther Med. 2024. PMID: 38800048 Free PMC article.
Sulfur metabolism as a new therapeutic target of heart failure.
Nishimura A, Tang X, Zhou L, Ito T, Kato Y, Nishida M. Nishimura A, et al. Among authors: kato y. J Pharmacol Sci. 2024 Jul;155(3):75-83. doi: 10.1016/j.jphs.2024.04.005. Epub 2024 Apr 23. J Pharmacol Sci. 2024. PMID: 38797536 Free article. Review.
8,502 results