Hruby VJ - Search Results

1

Novel fentanyl-based dual μ/δ-opioid agonists for the treatment of acute and chronic pain.

Podolsky AT, Sandweiss A, Hu J, Bilsky EJ, Cain JP, Kumirov VK, Lee YS, Hruby VJ, Vardanyan RS, Vanderah TW. Podolsky AT, et al. Among authors: hruby vj. Life Sci. 2013 Dec 18;93(25-26):1010-6. doi: 10.1016/j.lfs.2013.09.016. Epub 2013 Sep 29. Life Sci. 2013. PMID: 24084045 Free PMC article.

2

Synthesis and evaluation of 3-aminopropionyl substituted fentanyl analogues for opioid activity.

Petrov RR, Vardanyan RS, Lee YS, Ma SW, Davis P, Begay LJ, Lai JY, Porreca F, Hruby VJ. Petrov RR, et al. Among authors: hruby vj. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4946-50. doi: 10.1016/j.bmcl.2006.06.040. Epub 2006 Jul 7. Bioorg Med Chem Lett. 2006. PMID: 16828552 Free PMC article.

3

Synthesis and investigations of double-pharmacophore ligands for treatment of chronic and neuropathic pain.

Vardanyan R, Vijay G, Nichol GS, Liu L, Kumarasinghe I, Davis P, Vanderah T, Porreca F, Lai J, Hruby VJ. Vardanyan R, et al. Among authors: hruby vj. Bioorg Med Chem. 2009 Jul 15;17(14):5044-53. doi: 10.1016/j.bmc.2009.05.065. Epub 2009 Jun 2. Bioorg Med Chem. 2009. PMID: 19540763 Free PMC article.

4

Development of potent μ and δ opioid agonists with high lipophilicity.

Lee YS, Kulkarani V, Cowell SM, Ma SW, Davis P, Hanlon KE, Vanderah TW, Lai J, Porreca F, Vardanyan R, Hruby VJ. Lee YS, et al. Among authors: hruby vj. J Med Chem. 2011 Jan 13;54(1):382-6. doi: 10.1021/jm100982d. Epub 2010 Dec 3. J Med Chem. 2011. PMID: 21128594 Free PMC article.

5

Synthesis and biological evaluation of new opioid agonist and neurokinin-1 antagonist bivalent ligands.

Vardanyan R, Kumirov VK, Nichol GS, Davis P, Liktor-Busa E, Rankin D, Varga E, Vanderah T, Porreca F, Lai J, Hruby VJ. Vardanyan R, et al. Among authors: hruby vj. Bioorg Med Chem. 2011 Oct 15;19(20):6135-42. doi: 10.1016/j.bmc.2011.08.027. Epub 2011 Aug 24. Bioorg Med Chem. 2011. PMID: 21925887 Free PMC article.

6

Effect of anchoring 4-anilidopiperidines to opioid peptides.

Petrov RR, Lee YS, Vardanyan RS, Liu L, Ma SW, Davis P, Lai J, Porreca F, Vanderah TW, Hruby VJ. Petrov RR, et al. Among authors: hruby vj. Bioorg Med Chem Lett. 2013 Jun 1;23(11):3434-7. doi: 10.1016/j.bmcl.2013.03.065. Epub 2013 Apr 3. Bioorg Med Chem Lett. 2013. PMID: 23623418 Free PMC article.

7

Vardanyan RS, Hruby VJ. Vardanyan RS, et al. Among authors: hruby vj. Future Med Chem. 2014 Mar;6(4):385-412. doi: 10.4155/fmc.13.215. Future Med Chem. 2014. PMID: 24635521 Free PMC article. Review.

8

Dynorphin A analogs for the treatment of chronic neuropathic pain.

Hall SM, Lee YS, Hruby VJ. Hall SM, et al. Among authors: hruby vj. Future Med Chem. 2016;8(2):165-77. doi: 10.4155/fmc.15.164. Epub 2016 Jan 29. Future Med Chem. 2016. PMID: 26824470 Free PMC article. Review.

9

Cyclic Opioid Peptides.

Remesic M, Lee YS, Hruby VJ. Remesic M, et al. Among authors: hruby vj. Curr Med Chem. 2016;23(13):1288-303. doi: 10.2174/0929867323666160427123005. Curr Med Chem. 2016. PMID: 27117332 Free PMC article. Review.

10

Structure-Activity Relationships of [des-Arg⁷]Dynorphin A Analogues at the κ Opioid Receptor.

Ramos-Colon CN, Lee YS, Remesic M, Hall SM, LaVigne J, Davis P, Sandweiss AJ, McIntosh MI, Hanson J, Largent-Milnes TM, Vanderah TW, Streicher J, Porreca F, Hruby VJ. Ramos-Colon CN, et al. Among authors: hruby vj. J Med Chem. 2016 Nov 23;59(22):10291-10298. doi: 10.1021/acs.jmedchem.6b01411. Epub 2016 Nov 8. J Med Chem. 2016. PMID: 27797517 Free PMC article.

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