Ornstein PL - Search Results

1

GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy.

Martinez-Perez JA, Iyengar S, Shannon HE, Bleakman D, Alt A, Clawson DK, Arnold BM, Bell MG, Bleisch TJ, Castaño AM, Del Prado M, Dominguez E, Escribano AM, Filla SA, Ho KH, Hudziak KJ, Jones CK, Mateo A, Mathes BM, Mattiuz EL, Ogden AM, Simmons RM, Stack DR, Stratford RE, Winter MA, Wu Z, Ornstein PL. Martinez-Perez JA, et al. Among authors: ornstein pl. Bioorg Med Chem Lett. 2013 Dec 1;23(23):6463-6. doi: 10.1016/j.bmcl.2013.09.045. Epub 2013 Sep 24. Bioorg Med Chem Lett. 2013. PMID: 24140446

2

6-substituted decahydroisoquinoline-3-carboxylic acids as potent and selective conformationally constrained NMDA receptor antagonists.

Ornstein PL, Schoepp DD, Arnold MB, Augenstein NK, Lodge D, Millar JD, Chambers J, Campbell J, Paschal JW, Zimmerman DM, et al. Ornstein PL, et al. J Med Chem. 1992 Sep 18;35(19):3547-60. doi: 10.1021/jm00097a012. J Med Chem. 1992. PMID: 1404235

3

4-(Tetrazolylalkyl)piperidine-2-carboxylic acids. Potent and selective N-methyl-D-aspartic acid receptor antagonists with a short duration of action.

Ornstein PL, Schoepp DD, Arnold MB, Leander JD, Lodge D, Paschal JW, Elzey T. Ornstein PL, et al. J Med Chem. 1991 Jan;34(1):90-7. doi: 10.1021/jm00105a016. J Med Chem. 1991. PMID: 1825117

4

(3SR,4aRS,6RS,8aRS)-6-[2-(1H-tetrazol-5-yl)ethyl]decahydroisoquinoline-3 - carboxylic acid: a structurally novel, systemically active, competitive AMPA receptor antagonist.

Ornstein PL, Arnold MB, Augenstein NK, Lodge D, Leander JD, Schoepp DD. Ornstein PL, et al. J Med Chem. 1993 Jul 9;36(14):2046-8. doi: 10.1021/jm00066a016. J Med Chem. 1993. PMID: 8393116 No abstract available.

5

(3SR,4aRS,6SR,8aRS)-6-(1H-tetrazol-5-yl)decahydroisoquinoline-3-carboxylic acid, a novel, competitive, systemically active NMDA and AMPA receptor antagonist.

Ornstein PL, Arnold MB, Allen NK, Leander JD, Tizzano JP, Lodge D, Schoepp DD. Ornstein PL, et al. J Med Chem. 1995 Dec 8;38(25):4885-90. doi: 10.1021/jm00025a005. J Med Chem. 1995. PMID: 8523401

6

In vitro and in vivo antagonism of AMPA receptor activation by (3S, 4aR, 6R, 8aR)-6-[2-(1(2)H-tetrazole-5-yl) ethyl] decahydroisoquinoline-3-carboxylic acid.

Schoepp DD, Lodge D, Bleakman D, Leander JD, Tizzano JP, Wright RA, Palmer AJ, Salhoff CR, Ornstein PL. Schoepp DD, et al. Among authors: ornstein pl. Neuropharmacology. 1995 Sep;34(9):1159-68. doi: 10.1016/0028-3908(95)00099-r. Neuropharmacology. 1995. PMID: 8532186

7

Structure-activity studies of 6-(tetrazolylalkyl)-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 1. Effects of stereochemistry, chain length, and chain substitution.

Ornstein PL, Arnold MB, Allen NK, Bleisch T, Borromeo PS, Lugar CW, Leander JD, Lodge D, Schoepp DD. Ornstein PL, et al. J Med Chem. 1996 May 24;39(11):2219-31. doi: 10.1021/jm950912p. J Med Chem. 1996. PMID: 8667365

8

Structure-activity studies of 6-substituted decahydroisoquinoline-3-carboxylic acid AMPA receptor antagonists. 2. Effects of distal acid bioisosteric substitution, absolute stereochemical preferences, and in vivo activity.

Ornstein PL, Arnold MB, Allen NK, Bleisch T, Borromeo PS, Lugar CW, Leander JD, Lodge D, Schoepp DD. Ornstein PL, et al. J Med Chem. 1996 May 24;39(11):2232-44. doi: 10.1021/jm950913h. J Med Chem. 1996. PMID: 8667366

9

2-Substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 1. Effects of alkyl, arylalkyl, and diarylalkyl substitution.

Ornstein PL, Bleisch TJ, Arnold MB, Wright RA, Johnson BG, Schoepp DD. Ornstein PL, et al. J Med Chem. 1998 Jan 29;41(3):346-57. doi: 10.1021/jm970497w. J Med Chem. 1998. PMID: 9464366

10

2-substituted (2SR)-2-amino-2-((1SR,2SR)-2-carboxycycloprop-1-yl)glycines as potent and selective antagonists of group II metabotropic glutamate receptors. 2. Effects of aromatic substitution, pharmacological characterization, and bioavailability.

Ornstein PL, Bleisch TJ, Arnold MB, Kennedy JH, Wright RA, Johnson BG, Tizzano JP, Helton DR, Kallman MJ, Schoepp DD, Hérin M. Ornstein PL, et al. J Med Chem. 1998 Jan 29;41(3):358-78. doi: 10.1021/jm970498o. J Med Chem. 1998. PMID: 9464367

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