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Aqp5 is a new transcriptional target of Dot1a and a regulator of Aqp2.
Wu H, Chen L, Zhang X, Zhou Q, Li JM, Berger S, Borok Z, Zhou B, Xiao Z, Yin H, Liu M, Wang Y, Jin J, Blackburn MR, Xia Y, Zhang W. Wu H, et al. Among authors: zhang w, zhang x. PLoS One. 2013;8(1):e53342. doi: 10.1371/journal.pone.0053342. Epub 2013 Jan 10. PLoS One. 2013. PMID: 23326416 Free PMC article.
Elevated ecto-5'-nucleotidase-mediated increased renal adenosine signaling via A2B adenosine receptor contributes to chronic hypertension.
Zhang W, Zhang Y, Wang W, Dai Y, Ning C, Luo R, Sun K, Glover L, Grenz A, Sun H, Tao L, Zhang W, Colgan SP, Blackburn MR, Eltzschig HK, Kellems RE, Xia Y. Zhang W, et al. Among authors: zhang y. Circ Res. 2013 May 24;112(11):1466-78. doi: 10.1161/CIRCRESAHA.111.300166. Epub 2013 Apr 12. Circ Res. 2013. PMID: 23584256 Free PMC article.
Detrimental effects of adenosine signaling in sickle cell disease.
Zhang Y, Dai Y, Wen J, Zhang W, Grenz A, Sun H, Tao L, Lu G, Alexander DC, Milburn MV, Carter-Dawson L, Lewis DE, Zhang W, Eltzschig HK, Kellems RE, Blackburn MR, Juneja HS, Xia Y. Zhang Y, et al. Among authors: zhang w. Nat Med. 2011 Jan;17(1):79-86. doi: 10.1038/nm.2280. Epub 2010 Dec 19. Nat Med. 2011. PMID: 21170046 Free PMC article.
Af17 deficiency increases sodium excretion and decreases blood pressure.
Chen L, Wu H, Pochynyuk OM, Reisenauer MR, Zhang Z, Huang L, Zaika OL, Mamenko M, Zhang W, Zhou Q, Liu M, Xia Y, Zhang W. Chen L, et al. Among authors: zhang w, zhang z. J Am Soc Nephrol. 2011 Jun;22(6):1076-86. doi: 10.1681/ASN.2010121270. Epub 2011 May 5. J Am Soc Nephrol. 2011. PMID: 21546577 Free PMC article.
Aqp2-expressing cells give rise to renal intercalated cells.
Wu H, Chen L, Zhou Q, Zhang X, Berger S, Bi J, Lewis DE, Xia Y, Zhang W. Wu H, et al. Among authors: zhang w, zhang x. J Am Soc Nephrol. 2013 Feb;24(2):243-52. doi: 10.1681/ASN.2012080866. Epub 2013 Jan 10. J Am Soc Nephrol. 2013. PMID: 23308014 Free PMC article.
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