Stokes SS - Search Results

1

Identification through structure-based methods of a bacterial NAD(+)-dependent DNA ligase inhibitor that avoids known resistance mutations.

Murphy-Benenato K, Wang H, McGuire HM, Davis HE, Gao N, Prince DB, Jahic H, Stokes SS, Boriack-Sjodin PA. Murphy-Benenato K, et al. Among authors: stokes ss. Bioorg Med Chem Lett. 2014 Jan 1;24(1):360-6. doi: 10.1016/j.bmcl.2013.11.007. Epub 2013 Nov 15. Bioorg Med Chem Lett. 2014. PMID: 24287382

2

Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo.

Mills SD, Eakin AE, Buurman ET, Newman JV, Gao N, Huynh H, Johnson KD, Lahiri S, Shapiro AB, Walkup GK, Yang W, Stokes SS. Mills SD, et al. Among authors: stokes ss. Antimicrob Agents Chemother. 2011 Mar;55(3):1088-96. doi: 10.1128/AAC.01181-10. Epub 2010 Dec 28. Antimicrob Agents Chemother. 2011. PMID: 21189350 Free PMC article.

3

Discovery of bacterial NAD+-dependent DNA ligase inhibitors: optimization of antibacterial activity.

Stokes SS, Huynh H, Gowravaram M, Albert R, Cavero-Tomas M, Chen B, Harang J, Loch JT 3rd, Lu M, Mullen GB, Zhao S, Liu CF, Mills SD. Stokes SS, et al. Bioorg Med Chem Lett. 2011 Aug 1;21(15):4556-60. doi: 10.1016/j.bmcl.2011.05.128. Epub 2011 Jun 12. Bioorg Med Chem Lett. 2011. PMID: 21719282

4

In vitro validation of acetyltransferase activity of GlmU as an antibacterial target in Haemophilus influenzae.

Buurman ET, Andrews B, Gao N, Hu J, Keating TA, Lahiri S, Otterbein LR, Patten AD, Stokes SS, Shapiro AB. Buurman ET, et al. Among authors: stokes ss. J Biol Chem. 2011 Nov 25;286(47):40734-42. doi: 10.1074/jbc.M111.274068. Epub 2011 Oct 7. J Biol Chem. 2011. PMID: 21984832 Free PMC article.

5

Discovery of bacterial NAD⁺-dependent DNA ligase inhibitors: improvements in clearance of adenosine series.

Stokes SS, Gowravaram M, Huynh H, Lu M, Mullen GB, Chen B, Albert R, O'Shea TJ, Rooney MT, Hu H, Newman JV, Mills SD. Stokes SS, et al. Bioorg Med Chem Lett. 2012 Jan 1;22(1):85-9. doi: 10.1016/j.bmcl.2011.11.071. Epub 2011 Nov 23. Bioorg Med Chem Lett. 2012. PMID: 22154350

6

Inhibitors of acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 1: Hit to lead evaluation of a novel arylsulfonamide series.

Green OM, McKenzie AR, Shapiro AB, Otterbein L, Ni H, Patten A, Stokes S, Albert R, Kawatkar S, Breed J. Green OM, et al. Bioorg Med Chem Lett. 2012 Feb 15;22(4):1510-9. doi: 10.1016/j.bmcl.2012.01.016. Epub 2012 Jan 14. Bioorg Med Chem Lett. 2012. PMID: 22297115

7

Inhibitors of the acetyltransferase domain of N-acetylglucosamine-1-phosphate-uridylyltransferase/glucosamine-1-phosphate-acetyltransferase (GlmU). Part 2: Optimization of physical properties leading to antibacterial aryl sulfonamides.

Stokes SS, Albert R, Buurman ET, Andrews B, Shapiro AB, Green OM, McKenzie AR, Otterbein LR. Stokes SS, et al. Bioorg Med Chem Lett. 2012 Dec 1;22(23):7019-23. doi: 10.1016/j.bmcl.2012.10.003. Epub 2012 Oct 11. Bioorg Med Chem Lett. 2012. PMID: 23099094

8

Novel topoisomerase inhibitors: microbiological characterisation and in vivo efficacy of pyrimidines.

Uria-Nickelsen M, Neckermann G, Sriram S, Andrews B, Manchester JI, Carcanague D, Stokes S, Hull KG. Uria-Nickelsen M, et al. Int J Antimicrob Agents. 2013 Apr;41(4):363-71. doi: 10.1016/j.ijantimicag.2012.12.001. Epub 2013 Jan 8. Int J Antimicrob Agents. 2013. PMID: 23305654

9

New antibacterial agents: patent applications published in 2010.

Stokes SS, Morningstar M, Kocis H, Verheijen JC. Stokes SS, et al. Pharm Pat Anal. 2012 Nov;1(5):601-20. doi: 10.4155/ppa.12.59. Pharm Pat Anal. 2012. PMID: 24236928 Review.

10

First-in-Human Evaluation of the Safety, Tolerability, and Pharmacokinetics of SPR720, a Novel Oral Bacterial DNA Gyrase (GyrB) Inhibitor for Mycobacterial Infections.

Talley AK, Thurston A, Moore G, Gupta VK, Satterfield M, Manyak E, Stokes S, Dane A, Melnick D. Talley AK, et al. Antimicrob Agents Chemother. 2021 Oct 18;65(11):e0120821. doi: 10.1128/AAC.01208-21. Epub 2021 Sep 7. Antimicrob Agents Chemother. 2021. PMID: 34491803 Free PMC article. Clinical Trial.

Save citations to file

Email citations

Send citations to clipboard

Add to Collections

Add to My Bibliography

Create a file for external citation management software

Your saved search

Your RSS Feed

My NCBI Filters

Text availability

Article attribute

Article type

Publication date

18 results

Search Page