Cravatt BF - Search Results

1

Mechanistic characterization of a 2-thioxanthine myeloperoxidase inhibitor and selectivity assessment utilizing click chemistry--activity-based protein profiling.

Ward J, Spath SN, Pabst B, Carpino PA, Ruggeri RB, Xing G, Speers AE, Cravatt BF, Ahn K. Ward J, et al. Among authors: cravatt bf. Biochemistry. 2013 Dec 23;52(51):9187-201. doi: 10.1021/bi401354d. Epub 2013 Dec 9. Biochemistry. 2013. PMID: 24320749

2

Activity-based protein profiling in vivo using a copper(i)-catalyzed azide-alkyne [3 + 2] cycloaddition.

Speers AE, Adam GC, Cravatt BF. Speers AE, et al. Among authors: cravatt bf. J Am Chem Soc. 2003 Apr 23;125(16):4686-7. doi: 10.1021/ja034490h. J Am Chem Soc. 2003. PMID: 12696868

3

Chemical strategies for activity-based proteomics.

Speers AE, Cravatt BF. Speers AE, et al. Among authors: cravatt bf. Chembiochem. 2004 Jan 3;5(1):41-7. doi: 10.1002/cbic.200300721. Chembiochem. 2004. PMID: 14695510 Review.

4

Profiling enzyme activities in vivo using click chemistry methods.

Speers AE, Cravatt BF. Speers AE, et al. Among authors: cravatt bf. Chem Biol. 2004 Apr;11(4):535-46. doi: 10.1016/j.chembiol.2004.03.012. Chem Biol. 2004. PMID: 15123248

5

A tandem orthogonal proteolysis strategy for high-content chemical proteomics.

Speers AE, Cravatt BF. Speers AE, et al. Among authors: cravatt bf. J Am Chem Soc. 2005 Jul 20;127(28):10018-9. doi: 10.1021/ja0532842. J Am Chem Soc. 2005. PMID: 16011363 Free PMC article.

6

Tandem orthogonal proteolysis-activity-based protein profiling (TOP-ABPP)--a general method for mapping sites of probe modification in proteomes.

Weerapana E, Speers AE, Cravatt BF. Weerapana E, et al. Among authors: cravatt bf. Nat Protoc. 2007;2(6):1414-25. doi: 10.1038/nprot.2007.194. Nat Protoc. 2007. PMID: 17545978

7

Novel mechanistic class of fatty acid amide hydrolase inhibitors with remarkable selectivity.

Ahn K, Johnson DS, Fitzgerald LR, Liimatta M, Arendse A, Stevenson T, Lund ET, Nugent RA, Nomanbhoy TK, Alexander JP, Cravatt BF. Ahn K, et al. Among authors: cravatt bf. Biochemistry. 2007 Nov 13;46(45):13019-30. doi: 10.1021/bi701378g. Epub 2007 Oct 19. Biochemistry. 2007. PMID: 17949010

8

Enzymatic pathways that regulate endocannabinoid signaling in the nervous system.

Ahn K, McKinney MK, Cravatt BF. Ahn K, et al. Among authors: cravatt bf. Chem Rev. 2008 May;108(5):1687-707. doi: 10.1021/cr0782067. Epub 2008 Apr 23. Chem Rev. 2008. PMID: 18429637 Free PMC article. Review. No abstract available.

9

Structure-guided inhibitor design for human FAAH by interspecies active site conversion.

Mileni M, Johnson DS, Wang Z, Everdeen DS, Liimatta M, Pabst B, Bhattacharya K, Nugent RA, Kamtekar S, Cravatt BF, Ahn K, Stevens RC. Mileni M, et al. Among authors: cravatt bf. Proc Natl Acad Sci U S A. 2008 Sep 2;105(35):12820-4. doi: 10.1073/pnas.0806121105. Epub 2008 Aug 27. Proc Natl Acad Sci U S A. 2008. PMID: 18753625 Free PMC article.

10

Benzothiophene piperazine and piperidine urea inhibitors of fatty acid amide hydrolase (FAAH).

Johnson DS, Ahn K, Kesten S, Lazerwith SE, Song Y, Morris M, Fay L, Gregory T, Stiff C, Dunbar JB Jr, Liimatta M, Beidler D, Smith S, Nomanbhoy TK, Cravatt BF. Johnson DS, et al. Among authors: cravatt bf. Bioorg Med Chem Lett. 2009 May 15;19(10):2865-9. doi: 10.1016/j.bmcl.2009.03.080. Epub 2009 Mar 24. Bioorg Med Chem Lett. 2009. PMID: 19386497 Free PMC article.

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