Walensky LD - Search Results

1

Distinct BimBH3 (BimSAHB) stapled peptides for structural and cellular studies.

Bird GH, Gavathiotis E, LaBelle JL, Katz SG, Walensky LD. Bird GH, et al. Among authors: walensky ld. ACS Chem Biol. 2014 Mar 21;9(3):831-7. doi: 10.1021/cb4003305. Epub 2014 Jan 3. ACS Chem Biol. 2014. PMID: 24358963 Free PMC article.

2

Activation of apoptosis in vivo by a hydrocarbon-stapled BH3 helix.

Walensky LD, Kung AL, Escher I, Malia TJ, Barbuto S, Wright RD, Wagner G, Verdine GL, Korsmeyer SJ. Walensky LD, et al. Science. 2004 Sep 3;305(5689):1466-70. doi: 10.1126/science.1099191. Science. 2004. PMID: 15353804 Free PMC article.

3

Dissection of the BCL-2 family signaling network with stabilized alpha-helices of BCL-2 domains.

Pitter K, Bernal F, Labelle J, Walensky LD. Pitter K, et al. Among authors: walensky ld. Methods Enzymol. 2008;446:387-408. doi: 10.1016/S0076-6879(08)01623-6. Methods Enzymol. 2008. PMID: 18603135 Free PMC article.

4

BAX activation is initiated at a novel interaction site.

Gavathiotis E, Suzuki M, Davis ML, Pitter K, Bird GH, Katz SG, Tu HC, Kim H, Cheng EH, Tjandra N, Walensky LD. Gavathiotis E, et al. Among authors: walensky ld. Nature. 2008 Oct 23;455(7216):1076-81. doi: 10.1038/nature07396. Nature. 2008. PMID: 18948948 Free PMC article.

5

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer.

Stewart ML, Fire E, Keating AE, Walensky LD. Stewart ML, et al. Among authors: walensky ld. Nat Chem Biol. 2010 Aug;6(8):595-601. doi: 10.1038/nchembio.391. Epub 2010 Jun 20. Nat Chem Biol. 2010. PMID: 20562877 Free PMC article.

6

Hydrocarbon double-stapling remedies the proteolytic instability of a lengthy peptide therapeutic.

Bird GH, Madani N, Perry AF, Princiotto AM, Supko JG, He X, Gavathiotis E, Sodroski JG, Walensky LD. Bird GH, et al. Among authors: walensky ld. Proc Natl Acad Sci U S A. 2010 Aug 10;107(32):14093-8. doi: 10.1073/pnas.1002713107. Epub 2010 Jul 21. Proc Natl Acad Sci U S A. 2010. PMID: 20660316 Free PMC article.

7

BH3-triggered structural reorganization drives the activation of proapoptotic BAX.

Gavathiotis E, Reyna DE, Davis ML, Bird GH, Walensky LD. Gavathiotis E, et al. Among authors: walensky ld. Mol Cell. 2010 Nov 12;40(3):481-92. doi: 10.1016/j.molcel.2010.10.019. Mol Cell. 2010. PMID: 21070973 Free PMC article.

8

Photoreactive stapled BH3 peptides to dissect the BCL-2 family interactome.

Braun CR, Mintseris J, Gavathiotis E, Bird GH, Gygi SP, Walensky LD. Braun CR, et al. Among authors: walensky ld. Chem Biol. 2010 Dec 22;17(12):1325-33. doi: 10.1016/j.chembiol.2010.09.015. Chem Biol. 2010. PMID: 21168768 Free PMC article.

9

Tracking BAX once its trigger is pulled.

Gavathiotis E, Walensky LD. Gavathiotis E, et al. Among authors: walensky ld. Cell Cycle. 2011 Mar 15;10(6):868-70. doi: 10.4161/cc.10.6.15034. Epub 2011 Mar 15. Cell Cycle. 2011. PMID: 21325897 Free PMC article. No abstract available.

10

BAX unleashed: the biochemical transformation of an inactive cytosolic monomer into a toxic mitochondrial pore.

Walensky LD, Gavathiotis E. Walensky LD, et al. Trends Biochem Sci. 2011 Dec;36(12):642-52. doi: 10.1016/j.tibs.2011.08.009. Epub 2011 Oct 4. Trends Biochem Sci. 2011. PMID: 21978892 Free PMC article. Review.

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