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A randomised, phase II trial of the DNA-hypomethylating agent 5-aza-2'-deoxycytidine (decitabine) in combination with carboplatin vs carboplatin alone in patients with recurrent, partially platinum-sensitive ovarian cancer.
Glasspool RM, Brown R, Gore ME, Rustin GJ, McNeish IA, Wilson RH, Pledge S, Paul J, Mackean M, Hall GD, Gabra H, Halford SE, Walker J, Appleton K, Ullah R, Kaye S; Scottish Gynaecological Trials Group. Glasspool RM, et al. Among authors: mackean m. Br J Cancer. 2014 Apr 15;110(8):1923-9. doi: 10.1038/bjc.2014.116. Epub 2014 Mar 18. Br J Cancer. 2014. PMID: 24642620 Free PMC article. Clinical Trial.
Antiestrogen therapy is active in selected ovarian cancer cases: the use of letrozole in estrogen receptor-positive patients.
Smyth JF, Gourley C, Walker G, MacKean MJ, Stevenson A, Williams AR, Nafussi AA, Rye T, Rye R, Stewart M, McCurdy J, Mano M, Reed N, McMahon T, Vasey P, Gabra H, Langdon SP. Smyth JF, et al. Among authors: mackean mj. Clin Cancer Res. 2007 Jun 15;13(12):3617-22. doi: 10.1158/1078-0432.CCR-06-2878. Clin Cancer Res. 2007. PMID: 17575226 Free article. Clinical Trial.
How many cisplatin administration protocols does your department use?
Greystoke AP, Jodrell DI, Cheung M, Rivans I, Mackean MJ. Greystoke AP, et al. Among authors: mackean mj. Eur J Cancer Care (Engl). 2010 Jan 1;19(1):80-90. doi: 10.1111/j.1365-2354.2007.00908.x. Epub 2009 Aug 25. Eur J Cancer Care (Engl). 2010. PMID: 19708939 Review.
Increased incidence of visceral metastases in scottish patients with BRCA1/2-defective ovarian cancer: an extension of the ovarian BRCAness phenotype.
Gourley C, Michie CO, Roxburgh P, Yap TA, Harden S, Paul J, Ragupathy K, Todd R, Petty R, Reed N, Hayward RL, Mitchell P, Rye T, Schellens JH, Lubinski J, Carmichael J, Kaye SB, Mackean M, Ferguson M. Gourley C, et al. Among authors: mackean m. J Clin Oncol. 2010 May 20;28(15):2505-11. doi: 10.1200/JCO.2009.25.1082. Epub 2010 Apr 20. J Clin Oncol. 2010. PMID: 20406939
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