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Page 1
Polyfluorinated bis-styrylbenzenes as amyloid-β plaque binding ligands.
Nabuurs RJ, Kapoerchan VV, Metaxas A, de Jongh S, de Backer M, Welling MM, Jiskoot W, Windhorst AD, Overkleeft HS, van Buchem MA, Overhand M, van der Weerd L. Nabuurs RJ, et al. Among authors: windhorst ad. Bioorg Med Chem. 2014 Apr 15;22(8):2469-81. doi: 10.1016/j.bmc.2014.02.054. Epub 2014 Mar 7. Bioorg Med Chem. 2014. PMID: 24657049
Impact of molecular imaging on the diagnostic process in a memory clinic.
Ossenkoppele R, Prins ND, Pijnenburg YA, Lemstra AW, van der Flier WM, Adriaanse SF, Windhorst AD, Handels RL, Wolfs CA, Aalten P, Verhey FR, Verbeek MM, van Buchem MA, Hoekstra OS, Lammertsma AA, Scheltens P, van Berckel BN. Ossenkoppele R, et al. Among authors: windhorst ad. Alzheimers Dement. 2013 Jul;9(4):414-21. doi: 10.1016/j.jalz.2012.07.003. Epub 2012 Nov 16. Alzheimers Dement. 2013. PMID: 23164552 Free article. Clinical Trial.
Synthesis and preclinical evaluation of carbon-11 labelled N-((5-(4-fluoro-2-[(11)C]methoxyphenyl)pyridin-3-yl)methyl)cyclopentanamine as a PET tracer for NR2B subunit-containing NMDA receptors.
Christiaans JA, Klein PJ, Metaxas A, Kooijman EJ, Schuit RC, Leysen JE, Lammertsma AA, van Berckel BN, Windhorst AD. Christiaans JA, et al. Among authors: windhorst ad. Nucl Med Biol. 2014 Sep;41(8):670-80. doi: 10.1016/j.nucmedbio.2014.04.131. Epub 2014 May 10. Nucl Med Biol. 2014. PMID: 24929961
Subchronic treatment with phencyclidine in adolescence leads to impaired exploratory behavior in adult rats without altering social interaction or N-methyl-D-aspartate receptor binding levels.
Metaxas A, Willems R, Kooijman EJ, Renjaän VA, Klein PJ, Windhorst AD, Donck LV, Leysen JE, Berckel BN. Metaxas A, et al. Among authors: windhorst ad. J Neurosci Res. 2014 Nov;92(11):1599-607. doi: 10.1002/jnr.23433. Epub 2014 Jun 23. J Neurosci Res. 2014. PMID: 24953757
Preclinical evaluation of [(18)F]PK-209, a new PET ligand for imaging the ion-channel site of NMDA receptors.
Golla SS, Klein PJ, Bakker J, Schuit RC, Christiaans JA, van Geest L, Kooijman EJ, Oropeza-Seguias GM, Langermans JA, Leysen JE, Boellaard R, Windhorst AD, van Berckel BN, Metaxas A. Golla SS, et al. Among authors: windhorst ad. Nucl Med Biol. 2015 Feb;42(2):205-12. doi: 10.1016/j.nucmedbio.2014.09.006. Epub 2014 Sep 30. Nucl Med Biol. 2015. PMID: 25451213
Synthesis, structure activity relationship, radiolabeling and preclinical evaluation of high affinity ligands for the ion channel of the N-methyl-d-aspartate receptor as potential imaging probes for positron emission tomography.
Klein PJ, Christiaans JA, Metaxas A, Schuit RC, Lammertsma AA, van Berckel BN, Windhorst AD. Klein PJ, et al. Among authors: windhorst ad. Bioorg Med Chem. 2015 Mar 1;23(5):1189-206. doi: 10.1016/j.bmc.2014.12.029. Epub 2014 Dec 24. Bioorg Med Chem. 2015. PMID: 25648682
Quantification of the novel N-methyl-d-aspartate receptor ligand [11C]GMOM in man.
van der Doef TF, Golla SSV, Klein PJ, Oropeza-Seguias GM, Schuit RC, Metaxas A, Jobse E, Schwarte LA, Windhorst AD, Lammertsma AA, van Berckel BNM, Boellaard R. van der Doef TF, et al. Among authors: windhorst ad. J Cereb Blood Flow Metab. 2016 Jun;36(6):1111-21. doi: 10.1177/0271678X15608391. Epub 2015 Oct 5. J Cereb Blood Flow Metab. 2016. PMID: 26661185 Free PMC article.
Synthesis, radiolabeling and evaluation of novel amine guanidine derivatives as potential positron emission tomography tracers for the ion channel of the N-methyl-d-aspartate receptor.
Klein PJ, Chomet M, Metaxas A, Christiaans JA, Kooijman E, Schuit RC, Lammertsma AA, van Berckel BN, Windhorst AD. Klein PJ, et al. Among authors: windhorst ad. Eur J Med Chem. 2016 Aug 8;118:143-60. doi: 10.1016/j.ejmech.2016.04.022. Epub 2016 Apr 19. Eur J Med Chem. 2016. PMID: 27128179
Bis-pyridylethenyl benzene as novel backbone for amyloid-β binding compounds.
Nabuurs RJ, Kapoerchan VV, Metaxas A, Hafith S, de Backer M, Welling MM, Jiskoot W, van den Nieuwendijk AM, Windhorst AD, Overkleeft HS, van Buchem MA, Overhand M, van der Weerd L. Nabuurs RJ, et al. Among authors: windhorst ad. Bioorg Med Chem. 2016 Dec 1;24(23):6139-6148. doi: 10.1016/j.bmc.2016.05.022. Epub 2016 May 18. Bioorg Med Chem. 2016. PMID: 27838168
276 results