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Total synthesis and antifungal evaluation of cyclic aminohexapeptides.
Klein LL, Li L, Chen HJ, Curty CB, DeGoey DA, Grampovnik DJ, Leone CL, Thomas SA, Yeung CM, Funk KW, Kishore V, Lundell EO, Wodka D, Meulbroek JA, Alder JD, Nilius AM, Lartey PA, Plattner JJ. Klein LL, et al. Bioorg Med Chem. 2000 Jul;8(7):1677-96. doi: 10.1016/s0968-0896(00)00097-3. Bioorg Med Chem. 2000. PMID: 10976515
Enantioselective synthesis of antiinfluenza compound A-315675.
DeGoey DA, Chen HJ, Flosi WJ, Grampovnik DJ, Yeung CM, Klein LL, Kempf DJ. DeGoey DA, et al. Among authors: klein ll. J Org Chem. 2002 Aug 9;67(16):5445-53. doi: 10.1021/jo0162890. J Org Chem. 2002. PMID: 12153241
Synthesis, antiviral activity, and pharmacokinetic evaluation of P3 pyridylmethyl analogs of oximinoarylsulfonyl HIV-1 protease inhibitors.
Randolph JT, Huang PP, Flosi WJ, DeGoey D, Klein LL, Yeung CM, Flentge C, Sun M, Zhao C, Dekhtyar T, Mo H, Colletti L, Kati W, Marsh KC, Molla A, Kempf DJ. Randolph JT, et al. Among authors: klein ll. Bioorg Med Chem. 2006 Jun 15;14(12):4035-46. doi: 10.1016/j.bmc.2006.02.013. Epub 2006 Feb 28. Bioorg Med Chem. 2006. PMID: 16504523
2-Pyridyl P1'-substituted symmetry-based human immunodeficiency virus protease inhibitors (A-792611 and A-790742) with potential for convenient dosing and reduced side effects.
Degoey DA, Grampovnik DJ, Flentge CA, Flosi WJ, Chen HJ, Yeung CM, Randolph JT, Klein LL, Dekhtyar T, Colletti L, Marsh KC, Stoll V, Mamo M, Morfitt DC, Nguyen B, Schmidt JM, Swanson SJ, Mo H, Kati WM, Molla A, Kempf DJ. Degoey DA, et al. Among authors: klein ll. J Med Chem. 2009 Apr 23;52(8):2571-86. doi: 10.1021/jm900044w. J Med Chem. 2009. PMID: 19323562
Antitumor activity of 9(R)-dihydrotaxane analogs.
Klein LL, Li L, Maring CJ, Yeung CM, Thomas SA, Grampovnik DJ, Plattner JJ. Klein LL, et al. J Med Chem. 1995 Apr 28;38(9):1482-92. doi: 10.1021/jm00009a009. J Med Chem. 1995. PMID: 7739007
74 results