Spielmann HP - Search Results

1

Design and synthesis of non-hydrolyzable homoisoprenoid α-monofluorophosphonate inhibitors of PPAPDC family integral membrane lipid phosphatases.

Subramanian T, Ren H, Subramanian KL, Sunkara M, Onono FO, Morris AJ, Spielmann HP. Subramanian T, et al. Among authors: spielmann hp. Bioorg Med Chem Lett. 2014 Sep 15;24(18):4414-4417. doi: 10.1016/j.bmcl.2014.08.013. Epub 2014 Aug 12. Bioorg Med Chem Lett. 2014. PMID: 25150376 Free PMC article.

2

Functional characterization of the atypical integral membrane lipid phosphatase PDP1/PPAPDC2 identifies a pathway for interconversion of isoprenols and isoprenoid phosphates in mammalian cells.

Miriyala S, Subramanian T, Panchatcharam M, Ren H, McDermott MI, Sunkara M, Drennan T, Smyth SS, Spielmann HP, Morris AJ. Miriyala S, et al. Among authors: spielmann hp. J Biol Chem. 2010 Apr 30;285(18):13918-29. doi: 10.1074/jbc.M109.083931. Epub 2010 Jan 28. J Biol Chem. 2010. PMID: 20110354 Free PMC article.

3

Efficient use of exogenous isoprenols for protein isoprenylation by MDA-MB-231 cells is regulated independently of the mevalonate pathway.

Onono F, Subramanian T, Sunkara M, Subramanian KL, Spielmann HP, Morris AJ. Onono F, et al. Among authors: spielmann hp. J Biol Chem. 2013 Sep 20;288(38):27444-27455. doi: 10.1074/jbc.M113.482307. Epub 2013 Aug 1. J Biol Chem. 2013. PMID: 23908355 Free PMC article.

4

Directed library of anilinogeranyl analogues of farnesyl diphosphate via mixed solid- and solution-phase synthesis.

Subramanian T, Wang Z, Troutman JM, Andres DA, Spielmann HP. Subramanian T, et al. Among authors: spielmann hp. Org Lett. 2005 May 26;7(11):2109-12. doi: 10.1021/ol050386o. Org Lett. 2005. PMID: 15901146

5

Syntheses of deuterium labeled prenyldiphosphate and prenylcysteine analogues for in vivo mass spectrometric quantification.

Subramanian T, Subramanian KL, Sunkara M, Onono FO, Morris AJ, Spielmann HP. Subramanian T, et al. Among authors: spielmann hp. J Labelled Comp Radiopharm. 2013 Jun 30;56(8):370-5. doi: 10.1002/jlcr.3049. Epub 2013 May 9. J Labelled Comp Radiopharm. 2013. PMID: 24285475

6

Novel Citronellyl-Based Photoprobes Designed to Identify ER Proteins Interacting with Dolichyl Phosphate in Yeast and Mammalian Cells.

Rush JS, Subramanian T, Subramanian KL, Onono FO, Waechter CJ, Spielmann HP. Rush JS, et al. Among authors: spielmann hp. Curr Chem Biol. 2015;9(2):123-141. doi: 10.2174/2212796810666160216221610. Curr Chem Biol. 2015. PMID: 27099830 Free PMC article.

7

Hydrophilic anilinogeranyl diphosphate prenyl analogues are Ras function inhibitors.

Roberts MJ, Troutman JM, Chehade KA, Cha HC, Kao JP, Huang X, Zhan CG, Peterson YK, Subramanian T, Kamalakkannan S, Andres DA, Spielmann HP. Roberts MJ, et al. Among authors: spielmann hp. Biochemistry. 2006 Dec 26;45(51):15862-72. doi: 10.1021/bi061704+. Epub 2006 Dec 6. Biochemistry. 2006. PMID: 17176109

8

Selective modification of CaaX peptides with ortho-substituted anilinogeranyl lipids by protein farnesyl transferase: competitive substrates and potent inhibitors from a library of farnesyl diphosphate analogues.

Troutman JM, Subramanian T, Andres DA, Spielmann HP. Troutman JM, et al. Among authors: spielmann hp. Biochemistry. 2007 Oct 9;46(40):11310-21. doi: 10.1021/bi700516m. Epub 2007 Sep 14. Biochemistry. 2007. PMID: 17854205

9

Protein farnesyltransferase-catalyzed isoprenoid transfer to peptide depends on lipid size and shape, not hydrophobicity.

Subramanian T, Liu S, Troutman JM, Andres DA, Spielmann HP. Subramanian T, et al. Among authors: spielmann hp. Chembiochem. 2008 Nov 24;9(17):2872-82. doi: 10.1002/cbic.200800248. Chembiochem. 2008. PMID: 18985644 Free PMC article.

10

Farnesyl diphosphate analogues with aryl moieties are efficient alternate substrates for protein farnesyltransferase.

Subramanian T, Pais JE, Liu S, Troutman JM, Suzuki Y, Leela Subramanian K, Fierke CA, Andres DA, Spielmann HP. Subramanian T, et al. Among authors: spielmann hp. Biochemistry. 2012 Oct 16;51(41):8307-19. doi: 10.1021/bi3011362. Epub 2012 Oct 2. Biochemistry. 2012. PMID: 22989235 Free PMC article.

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