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A semi-mechanistic model for the effects of a novel glucagon receptor antagonist on glucagon and the interaction between glucose, glucagon, and insulin applied to adaptive phase II design.
Peng JZ, Denney WS, Musser BJ, Liu R, Tsai K, Fang L, Reitman ML, Troyer MD, Engel SS, Xu L, Stoch A, Stone JA, Kowalski KG. Peng JZ, et al. Among authors: xu l. AAPS J. 2014 Nov;16(6):1259-70. doi: 10.1208/s12248-014-9648-x. Epub 2014 Aug 27. AAPS J. 2014. PMID: 25160589 Free PMC article. Clinical Trial.
Long-term efficacy of sitagliptin as either monotherapy or add-on therapy to metformin: improvement in glycemic control over 2 years in patients with type 2 diabetes.
Katzeff HL, Williams-Herman D, Xu L, Golm GT, Wang H, Dong Q, Johnson JR, O'Neill EA, Kaufman KD, Engel SS, Goldstein BJ. Katzeff HL, et al. Among authors: xu l. Curr Med Res Opin. 2015 Jun;31(6):1071-7. doi: 10.1185/03007995.2015.1037259. Curr Med Res Opin. 2015. PMID: 25850968 Clinical Trial.
Initial therapy with the fixed-dose combination of sitagliptin and metformin results in greater improvement in glycaemic control compared with pioglitazone monotherapy in patients with type 2 diabetes.
Wainstein J, Katz L, Engel SS, Xu L, Golm GT, Hussain S, O'Neill EA, Kaufman KD, Goldstein BJ. Wainstein J, et al. Among authors: xu l. Diabetes Obes Metab. 2012 May;14(5):409-18. doi: 10.1111/j.1463-1326.2011.01530.x. Epub 2011 Dec 22. Diabetes Obes Metab. 2012. PMID: 22059736 Clinical Trial.
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